Plasma beta-endorphin and beta-lipotropin in the human fetus at delivery: correlation with arterial pH and pO2

The Journal of Clinical Endocrinology and Metabolism
S L WardlawA G Frantz

Abstract

Beta-endorphin-like immunoactivity was measured in the umbilical cord plasma of 45 term human fetuses. Mean concentration was 91 +/- 16 (SEM) pg/ml,an the normal adult level of 30.7 +/- 2.7 pg/ml. This immunoactivity was further characterized in 10 cases by Sephadex G-50 chromatography to separate beta-endorphin from beta-lipotropin (beta-LPH). Mean beta-endorphin and beta-LPH concentrations were 57 +/- 12.8 and 455 +/- 101 pg/ml, respectively. Both were higher (P less than 0.01) than the mean beta-endorphin and beta-LPH concentrations reported in the adult. The mean molar beta-endorphin to beta-LPH ratio was 0.35 in the fetus and 0.36 in the adult. In 17 fetuses whose umbilical arterial and venous concentrations were measured separately, mean beta-endorphin-like immunoactivity was higher in the artery than in the vein. A highly significant negative correlation (r = -0.831; P less than 0.001) was present between umbilical arteiral pH and beta-endorphin-like immunoactivity. A negative correlation (r = -0.611; P less than 0.005) with arterial pO2 was also noted. We conclude that high levels of beta-endorphin-like immunoactivity, composed of both beta-endorphin and beta-LPH, circulate in the human fetus at term, and that hypoxia a...Continue Reading

References

May 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·U GoebelsmannT T Hung
Feb 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M PohjavuoriT Laatikainen
Jul 1, 1985·Respiration Physiology·T RochatR C Gaillard
Nov 1, 1989·Respiration Physiology·A H JansenV Chernick
Feb 1, 1991·Respiration Physiology·M Pokorski, S Lahiri
Jan 1, 1988·Steroids·S Solomon
Jan 1, 1982·Progress in Neurobiology·R C Frederickson, L E Geary
Jan 1, 1989·Progress in Neurobiology·M Yeadon, I Kitchen
Sep 20, 1996·Early Human Development·S J RothenbergL A Guzmán
Mar 31, 2004·Seminars in Neonatology : SN·Jalal M Abu-Shaweesh
Sep 21, 2002·Lancet·John Bignall
Jun 6, 1981·Lancet·R DirksenG M Nijhuis
May 14, 1981·The New England Journal of Medicine·V Chernick
Jul 16, 2010·Journal of Paediatrics and Child Health·Olivier W V van den BrinkSalvatore Pepe
Jan 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·G NappiA R Genazzani
Oct 1, 1990·The American Review of Respiratory Disease·S BellofioreA Mistretta
Oct 1, 1990·The American Review of Respiratory Disease·J E ShookE M Camporesi
Jan 1, 1991·Journal of Perinatal Medicine·T K EskesV Ruth
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·T R Gunn, P D Gluckman
Jan 1, 1993·Medical Hypotheses·F DriesensP Janssen
Apr 1, 1981·Clinical Endocrinology·A R GenazzaniD Parrini
Mar 1, 1982·Clinics in Endocrinology and Metabolism·J S Winter
Sep 17, 1999·São Paulo Medical Journal = Revista Paulista De Medicina·A L PereiraB I Kopelman
Apr 1, 1983·Medical Hypotheses·T E Kuich, R A Franciosi
Nov 1, 1994·The American Journal of Emergency Medicine·J M Chamberlain, B L Klein
Jan 1, 1983·Respiration Physiology·W A Long, E E Lawson
Jun 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N Di SimoneS Mancuso
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W M Armstead
Jan 1, 1990·Annals of the New York Academy of Sciences·A VernadakisD Mangoura
Jan 1, 1983·British Journal of Obstetrics and Gynaecology·P A Riss, C Bieglmayer
Nov 19, 1987·The New England Journal of Medicine·K J Anand, P R Hickey
Jul 1, 1988·Archives of Disease in Childhood·T K Abboud
Sep 2, 1998·The American Journal of Physiology·W M Armstead
Jan 1, 1990·Annals of the New York Academy of Sciences·C A SandmanF J Zea

Related Concepts

Arterial Blood pH Measurement
Sephadex G
Arterial System
Dioxygen
Entire Fetus
Umbilicus (Anatomy)
Endorphins
Chromatography
Oxygen Measurement, Partial Pressure, Arterial
Umbilical Cord Structure

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.