Plasma beta-endorphin response to exercise in patients with congestive heart failure

Chest
G P PernaF Loperfido

Abstract

To determine whether the net release of beta-endorphin during exercise, similar to that of norepinephrine, is related to functional disability in patients with congestive heart failure. Plasma beta-endorphin and norepinephrine levels are elevated at rest in patients with heart failure, reflecting a functional disability. The net release of beta-endorphin during exercise in patients with heart failure is unknown. We measured plasma beta-endorphin and norepinephrine levels (respectively: radioimmune and radioenzymatic assay) at rest and during graded exercise testing in 28 patients with congestive heart failure (Weber's class A, 10; B, 9; and C, 9) and in 9 normal subjects. At rest, plasma beta-endorphin levels were higher in patients in classes B and C than in normal subjects (p < 0.05 and < 0.01, respectively). At peak exercise, patients in different functional classes and normal subjects reached similar beta-endorphin levels. However, the net release of beta-endorphin during exercise was lower in patients in classes B and C than in those in class A and normal subjects (p < 0.01 for both). At rest, plasma norepinephrine levels were significantly higher in patients than in normal subjects (p < 0.01). At peak exercise, norepineph...Continue Reading

References

Jan 1, 1991·Journal of the American College of Cardiology·S KawashimaT Iwasaki
Mar 15, 1989·Journal of the American College of Cardiology·W W Parmley
Jan 11, 1985·The American Journal of Cardiology·G S Francis
Feb 1, 1981·Metabolism: Clinical and Experimental·J E Morley

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Citations

Jan 8, 1999·Peptides·G A OlsonA J Kastin
Feb 2, 2013·Journal of Palliative Medicine·Stephen G OxberryMiriam J Johnson
Jan 31, 2012·Journal of Pain and Symptom Management·Miriam J JohnsonDavid C Currow
Feb 8, 2006·Journal of the American Geriatrics Society·Sue-Min LaiPamela W Duncan
Jun 30, 2011·European Journal of Heart Failure·Stephen G OxberryMiriam J Johnson
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M KlokeUNKNOWN ESMO Guidelines Committee

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