Plasma brain-derived neurotrophic factor in prepubertal obese children: results from a 2-year lifestyle intervention programme

Clinical Endocrinology
Raquel CorripioCaixàs Assumpta

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin potentially involved in the pathophysiology of obesity and metabolic syndrome in adults. In children, it has scarcely been studied. To analyse plasma BDNF and its relationship with metabolic syndrome components before and after 2 years of a lifestyle intervention programme in a prepubertal obese cohort. Case-control study with a 2-year prospective follow-up in a referral paediatric endocrine outpatient centre. Seventy-three prepubertal obese children, 8·03 ± 1·08 years old, and 47 age- and gender-matched lean controls were studied. Anthropometric parameters, blood pressure, platelet count (PLT), oral glucose tolerance test, homoeostatic model assessment for insulin resistance (HOMA-IR), lipid profile, BDNF, diet and physical activity were evaluated. Weight loss was considered if z-score body mass index (BMI) decreased at least 0·5 SD. At baseline, BDNF tended to be lower in prepubertal obese children compared with lean controls (P = 0·076). BDNF did not correlate with any metabolic syndrome component. After 2 years, obese patients showed an increase in BDNF. Regression model analysis adjusted by age, sex, puberty, BMI, PLT and HOMA-IR showed that BDNF increased in subje...Continue Reading

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Citations

Dec 3, 2014·Journal of Psychiatric Research·Kristin L SzuhanyMichael W Otto
Mar 26, 2013·Neuroscience and Biobehavioral Reviews·Alessandra Berry, Francesca Cirulli
Jul 6, 2014·Developmental Psychobiology·Igor Branchi, Francesca Cirulli
Oct 22, 2013·Physiology & Behavior·Chun-Jung HuangYoshimi Shibata
Aug 2, 2014·Progress in Neurobiology·Juvenal A RíosNibaldo C Inestrosa
May 27, 2014·Frontiers in Endocrinology·Nathalie CastanonLucile Capuron
Oct 9, 2012·Metabolism: Clinical and Experimental·Christian L RothThomas Reinehr
Feb 16, 2019·Journal of Neural Transmission·Andrea LászlóJános Nemcsik
Oct 22, 2019·Medicine and Science in Sports and Exercise·Jose Mora-GonzalezFrancisco B Ortega

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