PMID: 9426041Jan 13, 1998Paper

Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension

Journal of the American College of Cardiology
N NagayaK Kangawa

Abstract

This study sought to investigate the influence of right ventricular (RV) hemodynamic variables and function on the secretion of brain natriuretic peptide (BNP) in patients with isolated RV overload. Plasma BNP is known to increase in proportion to the degree of left ventricular (LV) overload. However, whether BNP secretion is also regulated in the presence of RV overload remains unknown. Plasma BNP and atrial natriuretic peptide (ANP) levels in the pulmonary artery were measured in 44 patients with RV overload: 18 with RV volume overload (RVVO) due to atrial septal defect and 26 with RV pressure overload (RVPO) due to primary or thromboembolic pulmonary hypertension. Right heart catheterization was performed in all patients. RV and LV ejection fraction, myocardial mass and volume of the four chambers were determined by using electron beam computed tomography. Although both plasma BNP and ANP levels were significantly elevated in patients with RV overload compared with values in control subjects, plasma BNP and the BNP/ANP ratio were significantly higher in patients with RVPO than with RVVO (BNP 294 +/- 72 vs. 48 +/- 14 pg/ml; BNP/ANP 1.6 +/- 0.2 vs. 0.8 +/- 0.2, both p < 0.05). Plasma BNP correlated positively with mean pulmona...Continue Reading

References

Jan 1, 1989·Journal of Cardiovascular Pharmacology·Y HirataH Matsuoka
Dec 1, 1987·Hypertension·P MontorsiA M Richards
Mar 3, 1988·Nature·T SudohH Matsuo
Jan 13, 1984·Biochemical and Biophysical Research Communications·K Kangawa, H Matsuo
Apr 1, 1994·Journal of Hypertension·N C Davidson, A D Struthers
Jan 1, 1993·The Journal of Clinical Endocrinology and Metabolism·S J HolmesC Frampton

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Jan 11, 2008·Pediatric Cardiology·Ruchira GargCurt J Daniels
Mar 31, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Arthur FiluschF Joachim Meyer
Jun 3, 2006·International Journal of Legal Medicine·Bao-Li ZhuHitoshi Maeda
Dec 23, 2006·The International Journal of Cardiovascular Imaging·Namik Kemal EryolNihat Kalay
Mar 9, 2007·Heart Failure Reviews·Michael A Burke, William G Cotts
Oct 5, 2010·Current Heart Failure Reports·Dipanjan BanerjeeJayan Nagendran
May 13, 2010·Cardiology in the Young·Julie SmithNiels Vejlstrup
Jul 6, 2010·European Heart Journal·Philipp KümpersMarius M Hoeper
Sep 19, 2012·International Journal of Rheumatology·Harpreet K Lota, Elisabetta A Renzoni
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·N NagayaK Miyatake
Apr 17, 2004·American Journal of Respiratory and Critical Care Medicine·Hanno H LeuchteJürgen Behr
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Babe BakouboulaFlorence Toti
Jan 16, 2008·Critical Care : the Official Journal of the Critical Care Forum·Joseph E LevittJohn P Kress
May 9, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Fumiaki OnoKunio Miyatake
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomoko UchinoKatsushige Ono
Aug 28, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·J MairB Puschendorf
Nov 18, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Claudio PassinoAldo Clerico
Jan 8, 2010·Drug Design, Development and Therapy·Brian Casserly, James R Klinger
Jun 12, 2010·Vascular Health and Risk Management·A PalazzuoliR Nuti
Dec 29, 2010·Medicinski pregled·Radomir MatunovićVioleta Rabrenović
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