PMID: 6993264Jul 1, 1980

Plasma C-peptide and serum insulin antibodies in diabetic patients receiving pancreatic transplants

Diabetologia
J OstmanG Lundgren

Abstract

Plasma C-peptide and serum insulin antibody levels were determined in 5 diabetic patients undergoing vascularized pancreatic transplantation. The grafts functioned well at first and exogenous insulin could be withdrawn, but one to 7 weeks later the grafts were rejected. After the transplantation there was an increase in the fasting plasma C-peptide level, and B-cell stimulation with glucose or glucagon evoked a C-peptide response. Healing of ischaemic damage was reflected in an increase in the C-peptide level. During graft rejection the C-peptide level fell. Measurement of plasma C-peptide levels provides a direct index of the B-cell function of the pancreatic graft. After transplantation the insulin antibody level fell exponentially, with an apparent half life of 10-11 days, whereas the level of total IgG was variable. The results indicate that formation of insulin antibodies ceases immediately on removal of the immunogenic stimulus, that is, on withdrawal of xenogeneic insulin.

References

Jun 10, 1998·Forensic Science International : Synergy·G Kernbach-Wighton, K Püschel
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nicolas DemartinesPierre-Alain Clavien
Feb 3, 2006·American Journal of Physiology. Cell Physiology·Janet B SchlesingerHans Hauner
Dec 11, 1985·International Journal of Technology Assessment in Health Care·G Tydén, C G Groth

Citations

Jan 1, 1978·Metabolism: Clinical and Experimental·D K YueJ R Turtle
Dec 1, 1976·Diabetologia·J Ludvigsson, L G Heding
Jun 1, 1975·The Journal of Clinical Investigation·D L HorwitzA H Rubenstein
Feb 12, 1972·Lancet·K DixonH R Hughes
May 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A H Christiansen
Sep 1, 1970·Annals of Surgery·R C LilleheiF C Goetz
Jan 1, 1972·Diabetes·J SCHLICHTKRULLK H Jorgensen
Jul 1, 1957·Acta Endocrinologica·D IKKOS, R LUFT
Jan 1, 1965·Acta Medica Scandinavica·J SCHLICHTKRULLM JERSILD

Related Concepts

Glucagon (rDNA)
C-Peptide
Glucagon
Pancreas Transplantation
Insulin C-peptide Measurement
B-Lymphocytes
Glucagon Measurement
Graft Rejection
Insulin Antibody Measurement
Polypeptides

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
H J KisslerP O Schwille
Zeitschrift für Rechtsmedizin. Journal of legal medicine
C F Hänsch, G De Roy
© 2020 Meta ULC. All rights reserved