Plasma carbonic anhydrase II protein is elevated in Alzheimer's disease

Journal of Alzheimer's Disease : JAD
Bong Geom JangYoung Ho Koh

Abstract

Carbonic anhydrase (CA) plays a critical role in pH regulation, long-term synaptic transformation, and is associated with mental retardation, Alzheimer's disease (AD), and Down syndrome. There is accumulating evidence that CAII is increased in AD brain. The present study focused on the determination of CAII protein level in blood plasma samples using immunoblot and ELISA methods. We compared plasma from 91 AD patients (average age 74.8 y), 83 persons with amnestic mild cognitive impairment (MCI) (average age 73.7 y), and 113 cognitively normal controls (average age 70.8 y). The plasma level of CAII was significantly increased in AD patients, as compared to control groups. CAII levels were higher in males than females. There was an age-dependent increase of CAII. These results provide further evidence that changes in CAII level may play a role in the pathogenesis of AD.

Citations

Nov 26, 2011·Antioxidants & Redox Signaling·D Allan ButterfieldRukhsana Sultana
Dec 20, 2017·Scientific Reports·Sun-Jung ChoYoung Ho Koh
Jul 10, 2018·Journal of Biochemical and Molecular Toxicology·Zuhal Alim
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Sun-Jung ChoYoung Ho Koh
Mar 22, 2019·Scientific Reports·Sun-Jung ChoYoung Ho Koh
Sep 27, 2019·International Journal of Molecular Sciences·Gustavo ProvensiSilvia Fossati
Apr 11, 2020·Cancers·Khalid O AlfaroukStephan J Reshkin
Aug 23, 2020·International Journal of Molecular Sciences·Todd J EckroatSeth C Cowan
Nov 27, 2019·PloS One·Sun-Jung ChoYoung Ho Koh
Sep 16, 2020·International Journal of Biological Macromolecules·Belgin SeverŞükrü Beydemir

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