PMID: 3751959Sep 1, 1986Paper

Plasma carnitine and renal-carnitine clearance during pregnancy

The American Journal of Clinical Nutrition
G CederbladK Lindgren

Abstract

This study assessed the time course of decrease in plasma carnitine during pregnancy and compared the renal clearance of carnitine during late pregnancy with nonpregnant women. As early as the 8th wk of pregnancy, the mean (+/- SD) value of total plasma-carnitine concentration in 19 women was significantly decreased from 39.0 +/- 6.3 to 32.8 +/- 4.6 mumol/l and the values continued to fall to 17.3 mumol/l by the 36th wk. The pattern was due to a fall in free-carnitine level; acylcarnitine remained unchanged. In 12 other women examined during late pregnancy, the renal clearance of acylcarnitine was significantly higher than in nonpregnant women, 53.9 +/- 29.4 versus 13.3 +/- 3.0 ml/min, in contrast to free carnitine, 3.5 +/- 2.8 versus 2.8 +/- 1.9 ml/min. Urinary excretion of carnitine (expressed per mol creatinine) did not differ between the two groups. Pregnant women showed sustained excretion of carnitine in the presence of low plasma-carnitine concentrations.

Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·P HarperG Cederblad
May 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·A LohningerR Marz
Jan 1, 1995·Journal of Perinatal Medicine·M SchoderbeckA Lohninger
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·W J TriggsL J Willmore
Jan 1, 1988·European Journal of Clinical Pharmacology·P HarperG Cederblad
Sep 1, 1995·Pediatric Pulmonology·A K IafollaC R Roe
Mar 13, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Ann E WesselGerard T Berry
Feb 27, 1998·Journal of the American College of Nutrition·N Takiyama, K Matsumoto
Oct 6, 2018·Clinical and Experimental Pharmacology & Physiology·Stefanie StangenbergSonia Saad
Nov 15, 1992·American Journal of Medical Genetics·S C Van CalcarJ A Wolff
Aug 26, 1998·Annual Review of Nutrition·C J Rebouche, H Seim
May 4, 2004·Obstetrics and Gynecology·Ingrit G I ThieleJan G Aarnoudse
Jun 25, 2005·The British Journal of Nutrition·Sang-Woon Cho, Youn-Soo Cha
Nov 9, 2019·The Journal of Biological Chemistry·Vytas A Bankaitis, Zhigang Xie
Jun 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A MarzoA Grignaffini
Jun 23, 2009·The British Journal of Nutrition·Klaus Eder
May 26, 2020·Biochemical and Biophysical Research Communications·Emiko SatoNobuyuki Takahashi
Aug 2, 2001·Journal of Pediatric and Adolescent Gynecology·E KoumantakisA Evageliou
Aug 1, 1994·Brain Research. Molecular Brain Research·M A VirmaniE Arrigoni-Martelli
Aug 1, 1990·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M SoopJ Wahren
Aug 20, 2021·Metabolomics : Official Journal of the Metabolomic Society·Albe SwanepoelIlse du Preez

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