PMID: 9178336May 1, 1997Paper

Plasma catecholamine and lymphocyte beta 2-adrenergic receptor alterations in elderly Alzheimer caregivers under stress

Psychosomatic Medicine
P J MillsI Grant

Abstract

The purpose of this study was to determine the effects of chronic stress on beta-adrenergic physiology in elderly spousal caregivers to Alzheimer patients. Thirty-seven elderly spousal caregivers and matched noncaregiver controls (mean age 73 years, SD = 6) were studied. Life stress categorization (presence of marked threat) covering the previous 6 months was determined using a semistructured interview based on the Psychiatric Epidemiological Research Inventory and the Life Events and Difficulties Schedule. beta 2-adrenergic receptor sensitivity (isoproterenol-stimulated cyclic AMP accumulation) and density were determined in lymphocytes. Caregivers with high life stress had higher plasma norepinephrine levels (p < .04) but no change in plasma cortisol. For beta-receptor sensitivity, 30% of the variance was accounted for by high life stress rating, increased age, being male, and lower norepinephrine (p = .018); 17% of the variance in beta-receptor density was accounted for by plasma norepinephrine (p = .03). The findings demonstrate that chronic high stress may be associated with changes in adrenergic physiology and may provide a mechanism through which chronic stress alters cellular immunity.

References

Jan 1, 1978·The Journal of Nervous and Mental Disease·B S Dohrenwend, B P Dohrenwend
Jul 1, 1978·Journal of Gerontology·G J PalmerC R Lake
Dec 1, 1992·Clinical Pharmacology and Therapeutics·A S NiesJ G Gerber
Jul 1, 1991·Psychosomatic Medicine·J K Kiecolt-GlaserR Glaser
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M IrwinI Grant
Jan 1, 1990·Annals of the New York Academy of Sciences·R H BonneauR Glaser
Aug 1, 1990·Hypertension·M C MichelP A Insel
Jan 1, 1990·Life Sciences·B Kennedy, M G Ziegler
Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·I GrantM R Trimble
Mar 1, 1988·Clinical Science·S L MaderP J Scarpace
Jan 1, 1984·Journal of Receptor Research·R M LandmannF R Bühler
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K B SeamonJ W Daly
Mar 1, 1984·The Journal of Clinical Investigation·R D FeldmanA J Wood
Jan 1, 1984·Annual Review of Physiology·A O Davies, R J Lefkowitz
Nov 4, 1995·Lancet·J K Kiecolt-GlaserR Glaser
Sep 15, 1994·Biological Psychiatry·B L ParryJ C Gillin
Jan 1, 1995·Hypertension·P J MillsR A Nelesen
Jul 1, 1994·Psychosomatic Medicine·J E DimsdaleE Dillon
Jan 1, 1993·Journal of the American College of Cardiology·P J MillsM R Brown
Mar 1, 1995·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·R R Freedman, M Moten

❮ Previous
Next ❯

Citations

May 21, 2013·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jennifer S HoBrent T Mausbach
Nov 6, 2003·Psychological Bulletin·Peter P VitalianoJames M Scanlan
Jul 15, 2004·Psychological Bulletin·Suzanne C Segerstrom, Gregory E Miller
Jul 18, 2003·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Roland von KänelIgor Grant
Feb 16, 1999·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·P P VitalianoE A Snyder
Aug 30, 2000·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·J T CacioppoR Glaser
Feb 26, 2016·Journal of Neuro-oncology·Paula R SherwoodAnna L Marsland
Dec 12, 2002·The Online Journal of Knowledge Synthesis for Nursing·Carol J. FarranJanice M. Zeller
Feb 14, 2004·Nursing Inquiry·Paula SherwoodMary Lovely
Apr 4, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Dolores Gallagher-ThompsonLarry W Thompson
Dec 27, 2005·Brain, Behavior, and Immunity·Jennifer E GrahamRonald Glaser
Jul 25, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kirstin AschbacherIgor Grant
Dec 14, 2006·Aging & Mental Health·D R BandeiraF N Hugo
Dec 14, 2011·Psychology & Health·Elizabeth A ChattillionIgor Grant
May 13, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan K Lutgendorf, Mark L Laudenslager
Jan 19, 2008·Psycho-oncology·Paula R SherwoodRichard Schulz
Jan 16, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Igor GrantThomas L Patterson
Jul 24, 2004·Psychosomatic Medicine·Andrew SherwoodAlan L Hinderliter
May 25, 2005·Psychosomatic Medicine·Philip M UllrichKarl J Kreder
Dec 5, 2009·Depression and Anxiety·Andrew W GoddardAnantha Shekhar
Mar 11, 2019·The Gerontologist·David L RothJeremy D Walston
Oct 17, 1998·Psychosomatic Medicine·J M ScanlanS Borson
Jan 31, 2002·Psychosomatic Medicine·Janice K Kiecolt-GlaserRonald Glaser
Jan 11, 2011·Psychosomatic Medicine·Susan K RoepkeIgor Grant
Oct 19, 2016·Current Opinion in Nephrology and Hypertension·Michael G Ziegler, Milos Milic
Mar 10, 1998·Psychosomatic Medicine·J E Dimsdale
Mar 11, 2003·CNS Spectrums·Michael H Antoni
Jul 28, 2011·Stress : the International Journal on the Biology of Stress·Susan K RoepkeIgor Grant
Jul 5, 2002·Brain, Behavior, and Immunity·Virginia M Sanders, Rainer H Straub
Jul 14, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Gelareh SadighRuth Carlos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.