Plasma catecholamines and haemodynamic changes during pneumoperitoneum

Acta Anaesthesiologica Scandinavica
K MyreO Stokland

Abstract

Insufflation of CO2 into the abdomen is used during all kinds of laparoscopic operations. The procedure elicits haemodynamic and hormonal responses. The reports on sympathetic responses to laparoscopic surgery have been conflicting. However, few studies have assessed sympathetic and haemodynamic responses to CO2 insufflation per se, eliminating possible effects of intubation, skin incision, surgical manipulation and positioning of the body. No studies have measured both venous and arterial plasma catecholamines, the latter being a more sensitive indicator of sympathetic activity. In the present study, we hypothesised an increased sympathetic activity during pneumoperitoneum and an association between haemodynamic and sympathetic responses. Plasma adrenaline and noradrenaline from the radial artery and superior vena cava were measured immediately before and 10 min after abdominal insufflation of CO2 in 11 subjects. Haemodynamics were monitored invasively. During pneumoperitoneum arterial plasma noradrenaline increased from 155 (106, 209) pg/ml (median, lowest and highest quartile) to 283 (188, 378) pg/ml (P = 0.003), while there were no changes in arterial plasma adrenaline. The calculated arterial-superior vena cava difference ...Continue Reading

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Citations

Aug 12, 2000·Acta Anaesthesiologica Scandinavica·A M Koivusalo, L Lindgren
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·H StormJ C Raeder
May 31, 2001·Journal of the American Geriatrics Society·D T Efron, J S Bender
Mar 17, 2007·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Bakiye UğurTarkan Tekten
Jun 28, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·C BraumannT Junghans
Jan 15, 2011·Anesthesia and Analgesia·Melinda LestarSuzanne Odeberg-Wernerman
Mar 9, 2005·Acta Anaesthesiologica Scandinavica·L E AnderssonS Odeberg-Wernerman
Mar 22, 2003·Acta Anaesthesiologica Scandinavica·K MyreO Stokland
Jun 14, 2003·Acta Anaesthesiologica Scandinavica·C A GreimJ Schulte am Esch
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·K MyreO Stokland
Feb 1, 2012·Acta Anaesthesiologica Scandinavica·L Ø HøisethK A Kirkebøen
May 1, 2008·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Amelia Oleaga, Fernando Goñi
Jan 25, 2017·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Benjamin LöserMartin Petzoldt
Jul 9, 2002·The Journal of the American Association of Gynecologic Laparoscopists·Ospan A MynbaevPhilippe R Koninckx
Jul 11, 2019·Clinical Endoscopy·Yun-Sic Bang, Chunghyun Park
Sep 14, 2019·Anesthesia and Analgesia·Benjamin LöserMartin Petzoldt
Aug 12, 2004·British Journal of Anaesthesia·M Lippmann, C Kakazu

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