Plasma catecholamines in rats exposed to cold: effects of ganglionic and adrenoreceptor blockade

European Journal of Pharmacology
G B PicottiM Da Prada

Abstract

Exposure to cold (4 degrees C) of catheterized rats acclimated to 20 degrees C resulted in a progressive increase in plasma noradrenaline (NA) concentrations which reached values consistently more than twice the basal ones (20 degrees C) by about 30 min. No further increase in plasma NA levels were detected when the cold exposure was continued for 24 h. Plasma adrenaline (A) and dopamine levels did not change at any time studied. Adrenalectomized rats exposed to cold exhibited percent rises in plasma NA similar to those in intact rats. An increase in plasma A levels concomitant with that of NA was observed following exposure to cold of rats in which either basal catecholamine release was impaired by chlorisondamine or the vasoconstrictor response was impeded by phentolamine. Propranolol did not modify the acute neurosympathetic response to cold. Exposure to cold (4 degrees C) for short periods of time combined with the measurement of plasma catecholamines is proposed as a useful and reproducible method for studying a pure neurosympathetic response in the rat.

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Citations

Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·G B PicottiJ Meldolesi
Sep 1, 1987·International Journal of Biometeorology·S DhingraB Singh
Nov 12, 1986·European Journal of Pharmacology·J Bhattacharyya, A G Datta
May 1, 1989·Clinical and Experimental Pharmacology & Physiology·C AlcarazM M Puig
Dec 29, 1995·Annals of the New York Academy of Sciences·R KvetnanskýI J Kopin
Aug 1, 1996·The Journal of Clinical Investigation·S N DavisR Mosqueda-Garcia
Nov 1, 1989·The British Veterinary Journal·A LocatelliG B Picotti
Dec 22, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Kurt McInnisÉric Doucet
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·P GalassettiS N Davis

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