Plasma Cell-Free DNA as a Predictive Marker after Radiotherapy for Hepatocellular Carcinoma

Yonsei Medical Journal
Sangjoon ParkJinsil Seong

Abstract

Cell-free DNA (cfDNA) is gaining attention as a novel biomarker for oncologic outcomes. We investigated the clinical significance of cfDNA in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT). Fifty-five patients with HCC who received RT were recruited from two prospective study cohorts: one cohort of 34 patients who underwent conventionally fractionated RT and a second of 21 patients treated with stereotactic body radiation therapy. cfDNA was extracted and quantified. In total, 30% of the patients had multiple tumors, 77% had tumors >2 cm, and 32% had portal vein tumor thrombus. Optimal cut-off values for cfDNA levels (33.65 ng/mL and 37.25 ng/mL, before and after RT) were used to divide patients into low-DNA (LDNA) and high-DNA (HDNA) groups. The pre-RT HDNA group tended to have more advanced disease and larger tumors (p=0.049 and p=0.017, respectively). Tumor response, intrahepatic failure-free rates, and local control (LC) rates were significantly better in the post-RT LDNA group (p=0.017, p=0.035, and p=0.006, respectively). Quantitative analysis of cfDNA was feasible in our cohorts. Post-RT cfDNA levels were negatively correlated with treatment outcomes, indicating the potential for the use of post-RT...Continue Reading

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Citations

Nov 7, 2019·International Journal of Molecular Sciences·Silvia MezzaliraGiuseppe Toffoli
Dec 10, 2019·Journal of Hematology & Oncology·Hongbo WangXiangxuan Zhao
Jan 3, 2021·Cancer Genetics·Cemal Çağıl KoçanaSelçuk Sözer
Mar 12, 2021·Frontiers in Cell and Developmental Biology·Yan-Yan YanJian-Ye Zhang
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Jun 3, 2021·Cancers·Filippo PelizzaroFabio Farinati
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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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