Plasma cell hepatitis in hepatitis C virus patients post-liver transplantation: case-control study showing poor outcome and predictive features in the liver explant

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Stephen C WardM Isabel Fiel

Abstract

Plasma cell hepatitis (PCH) is characterized by plasma cell infiltration seen in allografts of patients who underwent liver transplantation (LT) for conditions other than autoimmune hepatitis. We identified 40 PCH patients who underwent LT for hepatitis C virus (HCV) by searching our pathology database (1994-2006) for the keywords liver allograft, lymphoplasmacytic, and plasma cell(s). We selected 2 control patients who received LT for HCV for each PCH case. The control patients were matched according to date of LT and availability of biopsy material at the time interval to development of PCH in PCH patients. Explant and post-LT biopsy slides were blindly reviewed by 2 liver pathologists and the severity of the plasma cell infiltrate was scored. A score of 3 (plasma cells composing >30% of the infiltrate) defined PCH in allograft biopsies. Five random areas of dense inflammation were also examined in explant livers and the highest score was used. Poor outcome was defined as death or advanced fibrosis (stage >or= 4 of 6). We found that PCH patients were more likely to have worse outcomes than control patients (65% versus 40%, P < 0.01), including increased mortality (50% versus 30%, P < 0.05). Kaplan-Meier survival analysis show...Continue Reading

References

Nov 1, 1991·Journal of Hepatology·P J Scheuer
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J Czaja, H A Carpenter
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D E JonesM Hudson
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D J ReichP A Sheiner
May 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C K Tan, J M Sian Ho
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A HeneghanJ G O'Grady
Mar 26, 2002·Nature Reviews. Immunology·Carol L Vanderlugt, Stephen D Miller
May 31, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ernesto P MolmentiGoran B Klintmalm
Jul 17, 2004·Transplantation·Aya Miyagawa-HayashinoToshiaki Manabe
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Helen M EvansStefan Hübscher
Nov 4, 2006·Journal of Autoimmunity·Maite Duhalde-VegaLilia A Retegui
Mar 21, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Moataz SeyamStefan G Hübscher
May 24, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Wing-Kin SynJames M Neuberger
May 26, 2007·Transplantation Proceedings·H KhalafM Al-Sebayel
May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Anthony J Demetris, Mylene Sebagh
May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Isabel FielThomas D Schiano

❮ Previous
Next ❯

Citations

Jul 23, 2013·The Journal of Clinical Investigation·Anthony J BonitoKonstantina Alexandropoulos
Jan 25, 2013·World Journal of Gastroenterology : WJG·Eric R Kallwitz
Mar 25, 2014·World Journal of Gastroenterology : WJG·Francesco VasuriAntonia D'Errico-Grigioni
Apr 4, 2017·Clinics in Liver Disease·Eliza W BealAnthony Michaels
Aug 4, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Christine ChanJosh Levitsky
May 7, 2010·Current Opinion in Organ Transplantation·Ayse AytamanNorah A Terrault
Sep 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Md Mahmudul HasanHyeMee Joo
Mar 23, 2011·Current Opinion in Gastroenterology·Shari L Taylor, Salima Haque
Apr 14, 2012·Current Opinion in Organ Transplantation·M Isabel Fiel, Thomas D Schiano
May 28, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marwan GhabrilJustin H Nguyen
Jun 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J DemetrisY Zen
Oct 12, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshihide UedaShinji Uemoto
Dec 25, 2015·Clinical Transplantation·Carmen M StancaThomas D Schiano
Mar 15, 2016·World Journal of Gastroenterology : WJG·Ranka VukoticPietro Andreone
Aug 10, 2018·World Journal of Gastroenterology : WJG·Isabel AguileraAntonio Nuñez-Roldan
Jun 3, 2015·World Journal of Gastroenterology : WJG·Kieron B L LimThomas D Schiano
Jun 9, 2018·Transplantation Proceedings·J H KwonN N Zein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
M Isabel FielThomas D Schiano
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Nickolas KontorinisThomas D Schiano
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
James R Burton, Hugo R Rosen
© 2022 Meta ULC. All rights reserved