Plasma cell tumors with neurologic symptoms: cytological findings

Diagnostic Cytopathology
Negar AzarpiraAlireza Rasekhi

Abstract

Plasma cell neoplasms (plasma cell dyscrasias) are a group of entities characterized by the neoplastic proliferation of a single clone of plasma cells, typically producing a monoclonal immunoglobulin. These tumors can manifest as multiple myeloma, monoclonal gammopathy of undetermined significance, plasma cell myeloma, or plasmacytoma. We report two plasma cell tumors, one of them presented with headache and diplopia, and the second one complained from low back pain. The aspirate exhibited numerous plasma cells in various stage of maturation and was initially diagnosed as extra-skeletal solitary plasmacytoma on fine-needle aspiration cytology (FNAC). Immunohistochemistry demonstrated monoclonal expression of light immunoglobulin chains together with demonstration of CD 38 positivity. Systematic approach such as bone marrow examination, serum protein electrophoresis, skeletal imaging, and urine examination for Bence-Jones proteins were performed for patients. With these investigations, one case was labeled as multiple myeloma with secondary solitary plasmacytoma in pituitary gland and soft tissue and another one as primary extra-skeletal solitary plasmacytoma. Although fine-needle aspiration is a reliable and rapid technique for...Continue Reading

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Citations

Oct 12, 2011·Pituitary·Rene Joukhadar, Ken Chiu
Oct 2, 2013·Iranian Red Crescent Medical Journal·Mohamad Javad AshrafBita Valibeigi
Sep 13, 2013·Der Urologe. Ausg. A·M BöhmUNKNOWN Arbeitskreis Urinzytologie der DGU (Deutsche Gesellschaft für Urologie)
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Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Kai-Yu ZhouChi-Bo Liu
Feb 19, 2019·Spinal Cord Series and Cases·Steven D JacksonLeah R Hanson

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