Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation

Journal of Dairy Science
J E RicoJ W McFadden

Abstract

Insulin resistance is a homeorhetic adaptation to parturition in dairy cows transitioning from late pregnancy to early lactation. An increase in prepartum adiposity can predispose periparturient cows to greater lipolysis and insulin resistance, thus increasing the risk for metabolic disease. Mechanisms mediating the development of insulin resistance in overweight peripartal dairy cows may depend on ceramide metabolism. The sphingolipid ceramide accumulates in plasma and tissues of overweight monogastric animals, and facilitates saturated fatty acid-induced insulin resistance. Considering this evidence, we hypothesized that plasma ceramides would be elevated in periparturient dairy cattle and that these sphingolipids would correlate with the magnitude of lipolysis and insulin resistance. To test our central hypothesis, multiparous Holstein cows were allocated into 2 groups according to their body condition score (BCS) at d -30 prepartum: lean (BCS <3.0; n=10) or overweight (BCS >4.0; n=11). Blood samples were collected at d -45, -30, -15, and -7, relative to expected parturition, and at d 4 postpartum. Plasma glucose, insulin, nonesterified fatty acids (NEFA), and β-hydroxybutyrate (BHBA) concentrations were measured, and insuli...Continue Reading

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Citations

Oct 19, 2016·Animal : an International Journal of Animal Bioscience·E HumerQ Zebeli
Mar 26, 2015·PloS One·Pilar Sepúlveda-VarasMarina A G von Keyserlingk
Nov 26, 2010·Journal of Dairy Science·J DubucS J LeBlanc
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Nov 30, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Mika, T Sledzinski
Feb 6, 2018·Journal of Dairy Science·J E RicoJ W McFadden
Nov 21, 2017·Journal of Dairy Science·T R OvertonD V Nydam
Aug 28, 2017·Journal of Dairy Science·C S KrummY R Boisclair
Oct 4, 2018·The Journal of Nutrition·J Eduardo RicoJoseph W McFadden
Jul 16, 2019·Journal of Dairy Science·J W McFadden, J E Rico
Feb 7, 2020·Animal : an International Journal of Animal Bioscience·J W McFadden

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