Plasma Chemokine CCL2 and Its Receptor CCR2 Concentrations as Diagnostic Biomarkers for Breast Cancer Patients

BioMed Research International
Emilia LubowickaSławomir Ławicki

Abstract

The aim of this study was to investigate plasma levels and applicability of CCL2, CCR2, and tumor marker CA 15-3 in breast cancer (BC) patients and in relation to the control groups: patients with benign breast tumor and healthy subjects. Plasma levels of tested parameters were determined by enzyme-linked immunosorbent assay (ELISA) and CA 15-3 by Chemiluminescent Microparticle Immunoassay (CMIA). The median levels of CCL2 in entire group of BC were significantly higher compared to the control groups, similarly as median levels of CA 15-3. CCR2 is a negative marker whose levels were significantly lower in BC group compared to healthy women. The concentration of CCL2 in BC increases with advancing tumor stage, while a median level of CCR2 decreases with advancing stage. CCL2 showed the highest value of sensitivity (SE) (64.95%) in entire BC group and also in early stages of disease. The highest specificity (SP) was obtained by CA 15-3 (85.71%). The area under the ROC curve (AUC) of CCR2 (0.7304) was the largest of all the tested parameters (slightly lower than CA 15-3) in the entire BC group, but a maximum range was obtained for the combination of all tested parameters with CA 15-3 (0.8271). In early stages of BC the highest AUC...Continue Reading

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Citations

Jan 11, 2020·Frontiers in Immunology·Martha GschwandtnerKim S Midwood
Nov 19, 2020·International Journal of Molecular Sciences·Monika Gudowska-SawczukBarbara Mroczko
Feb 6, 2021·International Journal of Molecular Sciences·Sebastian Dommel, Matthias Blüher
Dec 19, 2020·Biomedicines·Natalia RybtsovaStanislav Rybtsov
Apr 30, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriela Martínez-ChacónSari Mäkelä

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Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GraphRoc
STATISTICA

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