Plasma cholecystokinin and gallbladder responses to increasing doses of bombesin in celiac disease

Digestive Diseases and Sciences
P W ThimisterJ B Jansen

Abstract

Impaired postprandial gallbladder emptying in celiac disease has been attributed to an absence of appropriate cholecystokinin release. To determine if a flat jejunal mucosa in celiac patients is related to a reduced cholecystokinin-secreting capacity, increasing doses of bombesin were infused into six patients with celiac disease and a flat jejunal mucosa (group A), in seven celiac patients with a normal jejunal mucosa while on a gluten-free diet (group B), and in seven healthy controls (group C). Bombesin induced significant (P < 0.05) increments of plasma CCK to a maximum value of 1.0 +/- 0.3 pM in group A, to 1.5 +/- 0.3 pM in group B, and to 1.2 +/- 0.3 pM in group C (NS between groups), that were accompanied by significant (P < 0.05) gallbladder emptying responses of 70 +/- 4% in group A, 47 +/- 10% in group B and 65 +/- 5% in group C. Dose-response relationships were not different between groups. We conclude that there is no major impairment of gallbladder responsiveness to bombesin or of cholecystokinin-secreting capacity in patients with a flat jejunal mucosa due to celiac disease.

Citations

May 31, 2001·European Journal of Clinical Investigation·J Walkowiak, K H Herzig
Aug 27, 2005·Scandinavian Journal of Gastroenterology·Luca Elli, Maria Teresa Bardella
Apr 14, 2005·Clinical Nuclear Medicine·Attila SzepesLászló Madácsy

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