Plasma clearance and half-life of prostaglandin F2alpha: a comparison between mares and heifers

Biology of Reproduction
H K ShresthaO J Ginther

Abstract

Horses are about five times more sensitive to the luteolytic effect of prostaglandin F2alpha (PGF) than cattle, as indicated by a recommended clinical dose of 5 mg in horses and 25 mg in cattle. Novel evaluations of the PGF plasma disappearance curves were made in mares and in heifers, and the two species were compared. Mares and heifers (n = 5) of similar body weight were injected (Min 0) intravenously with PGF (5 mg per animal). Blood was sampled every 10 sec until Min 3, every 30 sec until Min 5, every 10 min until Min 60, and every 30 min until Min 240. The mean PGF concentration was greater (P < 0.05) in mares than in heifers at Min 1 through Min 60 and at Mins 180 and 240. The mean time to maximum PGF concentration was not different between mares (42.0 ± 8.6 sec) and heifers (35.0 ± 2.9 sec). The apparent plasma clearance, distribution half-life, elimination half-life, and maximum plasma PGF concentration were 3.3 ± 0.5 L h(-1) kg(-1), 94.2 ± 15.9 sec, 25.9 ± 5.0 min, and 249.1 ± 36.8 ng/ml, respectively, in mares and 15.4 ± 2.3 L h(-1) kg(-1), 29.2 ± 3.9 sec, 9.0 ± 0.9 min, and 51.4 ± 22.6 ng/ml, respectively, in heifers. Plasma clearance was about five times less (P < 0.0005), maximum plasma PGF concentration was five t...Continue Reading

References

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Citations

Feb 26, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Keisuke KozaiKiyoshi Okuda
Dec 10, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·S T BashirEduardo L Gastal
May 16, 2017·Clinical and Experimental Pharmacology & Physiology·Gabriel Mayoral-AndradeEduardo Pérez-Campos
Jun 21, 2013·Reproduction in Domestic Animals = Zuchthygiene·T S AguiarL R Martins
Dec 20, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Zhichao ZhangAmeer Y Taha

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