PMID: 8948446Jun 15, 1995Paper

Plasma clearance of rat bikunin: evidence for receptor-mediated uptake

The Biochemical Journal
E M SjöbergE Fries

Abstract

Bikunin is a chondroitin sulphate-containing protease inhibitor with a molecular mass of 25 kDa. It is secreted into the blood by hepatocytes, and recent observations indicate that it may have an extravascular function. Here we have studied the plasma clearance of bikunin in rats and mice. On intravenous injection, radiolabelled bikunin was found to have a half-life of 10 min; in rats with ligated renal arteries, the clearance time was twice as long, implying that the kidneys account for half the uptake. As judged by gel filtration, the size of bikunin is similar to that of albumin. Autoradiographic analysis of kidneys removed 2 min after the injection of radiolabelled bikunin indicated that, despite its size, bikunin is cleared by glomerular filtration. On ligation of the renal arteries, the plasma concentration of bikunin increased linearly to at least four times normal. This finding shows that the non-renal uptake system is saturated and therefore presumably receptor-mediated. Most of the non-renal uptake of injected bikunin was found to occur in non-visceral tissues such as the skin. Analysis of skin samples by autoradiography after injection of radiolabelled bikunin suggested that bikunin had been transferred from the plas...Continue Reading

Citations

Sep 1, 1999·The Journal of Investigative Dermatology·C Y CuiT Tezuka
Jan 23, 1999·European Journal of Biochemistry·N Martin-VandeletM Diarra-Mehrpour
Sep 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Charlotte MizonJacques Mizon
Apr 9, 2008·Physiological Reviews·Börje HaraldssonWilliam M Deen
Jul 6, 2019·Journal of Neuropathology and Experimental Neurology·Adriel Barrios-AndersonBarbara S Stonestreet
May 11, 2005·Molecular and Cellular Biochemistry·Aneta KaczmarczykErik Fries
Jun 16, 2001·American Journal of Physiology. Renal Physiology·M OhlsonB Haraldsson
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·LiLi TuDouglas A Steeber
Dec 6, 2020·International Journal of Molecular Sciences·Liam M KoehnBarbara S Stonestreet
Mar 3, 1998·Biochemical and Biophysical Research Communications·Y KatoK Hoshida
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·E Fries, A M Blom
Oct 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M BlomE Fries
May 8, 1999·Journal of the American Society of Nephrology : JASN·S IidaS R Khan
Sep 29, 2021·The Journal of Clinical Investigation·Louise D McCulloughVenugopal Reddy Venna

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