PMID: 8966499Jan 1, 1996Paper

Plasma concentration of estradiol following transdermal administration of Systen 50 or Menorest 50

Scandinavian Journal of Rheumatology. Supplement
J Y ReginsterP Franchimont

Abstract

Circulating levels of 17 beta estradiol (E2) following the administration of fixed doses of E2, show a great variability in kinetics depending upon the product administrated, the routes of administration, and the interindividual variations in absorption and metabolism. This might have important implications both in terms of tolerance and effectiveness. Two new forms of transdermal E2 (SYSTEN Cilag and MENOREST Rhone-Poulenc Rorer) have been recently accepted in Europe for the treatment of climacteric symptoms. The present study was undertaken to compare the pharmacokinetic characteristics of plasma E2 profile under these two drugs. It was carried out in 30 healthy postmenopausal volunteers according to good clinical practice after informed consent, as a single blind, randomised, cross-over study during the classical wearing period of 4 days. Plasma E2 concentration was determined 24 hours before, 1/2 hour before and then 2, 4, 8, 12, 24, 48, 72, 84, 96 hours after the first patch administration. E2 measurement was performed using a specific direct radioimmunoassay developed in the FRH laboratories. The main criteria for this method were an intraassay coefficient of variation (CV) less than 6%, an interassay CV less than 8% in a...Continue Reading

References

Oct 1, 1992·Maturitas·J Coope, J Marsh
May 1, 1987·American Journal of Obstetrics and Gynecology·V A Ravnikar
Jul 1, 1983·Journal of Steroid Biochemistry·K Fotherby

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