PMID: 8489055May 1, 1993Paper

Plasma concentration of fentanyl, with 70% nitrous oxide, to prevent movement at skin incision

P S GlassL R Smith


The Cp50 (minimal steady state plasma concentration of an intravenous analgesic/anesthetic required to prevent a somatic response in 50% of patients following skin incision) and the Cp50-BAR (minimal plasma concentration of an analgesic/anesthetic required to prevent either a somatic, hemodynamic, or autonomic response in 50% of patients following skin incision) have been recently proposed as a measure, like minimum alveolar concentration (MAC; and MAC-BAR), to establish the relative potency of intravenous analgesics. This study was conducted to establish the Cp50 for fentanyl. Unpremedicated patients were administered fentanyl (in the presence of 70% N2O) via computer-assisted continuous infusion, a pharmacokinetic model-driven infusion device. After induction of anesthesia with fentanyl, the randomized target fentanyl concentration was entered into computer-assisted continuous infusion. This target fentanyl concentration was maintained until skin incision. Before induction, prior to skin incision, and immediately after skin incision, arterial blood samples were obtained for measurement of fentanyl and norepinephrine concentrations. At skin incision, patients were observed for a somatic, hemodynamic, or autonomic response. Onl...Continue Reading


Nov 1, 1995·Journal of Clinical Anesthesia·P S Glass
Aug 17, 2001·International Anesthesiology Clinics·Y NakataS Morita
Oct 1, 1996·Acta Anaesthesiologica Scandinavica·T Heier, P A Steen
Oct 1, 1996·Acta Anaesthesiologica Scandinavica·T Heier, P A Steen
Oct 1, 1995·Anesthesia and Analgesia·B S ChortkoffP Ionescu
Sep 5, 1998·Anesthesia and Analgesia·J W JohansenP S Sebel
Jul 18, 2008·Anesthesia and Analgesia·Jan F A HendrickxSteven L Shafer
Jan 15, 2000·Journal of Neurosurgical Anesthesiology·J P ColesA K Gupta
Dec 1, 1996·Anesthesiology·B GinsbergS L Shafer
Oct 8, 1999·Anesthesia and Analgesia·Peter S A GlassScott Howell

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