Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Lancet
P M RidkerJ Allen

Abstract

The intercellular adhesion molecule ICAM-1 mediates adhesion and transmigration of leucocytes to the vascular endothelial wall, a step proposed to be critical in the initiation and progression of atherosclerosis. Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown. We obtained baseline plasma samples from a prospective cohort of 14,916 healthy men enrolled in the Physicians' Health Study. With a nested case-control design, we measured sICAM-1 concentrations for 474 participants who developed a first myocardial infarction, and 474 controls (participants who remained healthy throughout the 9-year follow-up). Cases were matched to controls according to age and smoking status at the time of myocardial infarction. We found a significant association between increasing concentration of sICAM-1 and risk of future myocardial infarction (p = 0.003), especially among participants with baseline sICAM-1 concentrations in the highest quartile (> 260 ng/mL; relative risk 1.6 [95% Cl 1.1-2.4], p = 0.02). This association was present overall as well as among non-smokers, and persisted after control for lipid and non-lipid risk factors. In multiva...Continue Reading

References

Sep 16, 1992·Biochemical and Biophysical Research Communications·R PigottA J Gearing
Aug 2, 1990·Nature·T A Springer
Jan 1, 1994·Annual Review of Medicine·M P BevilacquaO Cecconi
Jun 1, 1995·Circulation·P Libby
Dec 1, 1994·Journal of the American College of Cardiology·Y JangE J Topol
Nov 10, 1993·JAMA : the Journal of the American Medical Association·P M RidkerM J Stampfer
Apr 1, 1996·Circulation·A HackmanC M Ballantyne
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Mar 18, 1997·Circulation·E F Plow, S E D'Souza
Jun 13, 1997·The Journal of Biological Chemistry·E E Gardiner, S E D'Souza

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Citations

Apr 16, 2002·Arthritis and Rheumatism·S Van DoornumI P Wicks
May 1, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·F G Welt, D I Simon
Dec 18, 2001·Journal of Magnetic Resonance Imaging : JMRI·C R WeissR O Cannon
Sep 15, 2006·Current HIV/AIDS Reports·Bruno R Cotter
Apr 27, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jihyun LeeStephen Desiderio
Aug 9, 2012·European Journal of Nutrition·R J WidmerA Lerman
Feb 7, 2007·Sleep & Breathing = Schlaf & Atmung·Mónica de la Peña BravoDavid Gozal
Jan 5, 2002·Current Atherosclerosis Reports·Christopher C Case, Christie M Ballantyne
Aug 7, 2002·Current Atherosclerosis Reports·Andrea HarrisIshwarlal Jialal
Jun 10, 2003·Current Atherosclerosis Reports·Kiat T TanAndrew D Blann
Feb 4, 2003·Current Atherosclerosis Reports·Joshua M Spin, Randall H Vagelos
Apr 8, 2004·Current Atherosclerosis Reports·Rajagopal V SekharAshok Balasubramanyam
Feb 25, 2005·Current Atherosclerosis Reports·Guilherme H M Oliveira
Apr 2, 2008·Current Atherosclerosis Reports·Frederick F SamahaAngela P Makris
Jun 8, 2002·Current Cardiology Reports·Joshua M SpinUNKNOWN American Heart Association
Mar 9, 2006·Current Diabetes Reports·Raffaelle Bugiardini
Apr 26, 2006·Current Treatment Options in Cardiovascular Medicine·Hakon Hakonarson
Apr 3, 2012·Indian Journal of Clinical Biochemistry : IJCB·Subinay DattaK R Prasad
May 26, 2004·Brain, Behavior, and Immunity·Paul J Mills, Joel E Dimsdale
May 28, 2005·Cytokine·Anna Maria Witkowska
Mar 31, 2009·European Journal of Internal Medicine·Arnon Blum
Feb 10, 2004·Metabolism: Clinical and Experimental·Fahim AbbasiGerald M Reaven
Feb 28, 2002·The American Journal of Cardiology·Sanjay RajagopalanBertram Pitt
May 4, 2002·The American Journal of Cardiology·Edmund A BermudezPaul M Ridker
Nov 7, 2000·The American Journal of Medicine·N S Cherniack
Jul 14, 1999·The American Journal of Medicine·D T Price, J Loscalzo
Feb 4, 1999·The Annals of Thoracic Surgery·G Asimakopoulos, K M Taylor
Mar 4, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·J E PaikerN H Naran

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