Plasma concentration of urokinase plasminogen activator receptor is a marker of kidney allograft function

Irish Journal of Medical Science
Marzena StaniszewskaAndrzej Pawlik

Abstract

Urokinase-type plasminogen activator receptor (uPAR) is found in a variety of cell types including monocytes, lymphocytes, macrophages, and endothelial cells and plays an important role in fibrinolysis and in the activation and chemotaxis of neutrophils and lymphocytes. In this study, we examined the correlation between uPAR plasma concentration and kidney allograft function. This study enrolled 78 Caucasian deceased-donor renal transplant recipients. Plasma concentrations of uPAR were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits. We observed elevated with borderline significance (p = 0.095) uPAR plasma concentrations in patients with tubular atrophy. Plasma concentrations of uPAR showed strong statistically significant positive correlations with serum creatinine or urea and strong negative correlation with estimated glomerular filtration rate (eGFR). There was also a borderline positive correlation between uPAR plasma concentration and protein concentration in urine as well as the duration of hemodialysis. The results of our study indicate that uPAR plasma concentrations in kidney allograft recipients are significantly negatively correlated with graft function and may be elevated in pati...Continue Reading

References

Sep 29, 1999·Transplantation Proceedings·J TorrasJ M Grinyo
Sep 30, 2000·Kidney International·P LuimulaH Holthöfer
Oct 9, 2003·Kidney International·Joris J T H RoelofsSandrine Florquin
Dec 18, 2007·Nature Medicine·Changli WeiJochen Reiser
Dec 29, 2009·FEBS Letters·Francesco Blasi, Nicolai Sidenius
Aug 2, 2011·Nature Medicine·Changli WeiJochen Reiser
Dec 14, 2012·Kidney International·Kim Solez, Lorraine C Racusen
Oct 30, 2014·Kidney International·Joann M SpinaleUNKNOWN Nephrotic Syndrome Study Network
Nov 6, 2015·The New England Journal of Medicine·Salim S HayekJochen Reiser
Mar 11, 2016·The New England Journal of Medicine·Salim S HayekJochen Reiser
Mar 11, 2016·The New England Journal of Medicine·Marco QuagliaVincenzo Cantaluppi
Mar 11, 2016·The New England Journal of Medicine·Martin SchumacherJan Beyersmann

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Citations

Sep 29, 2020·Frontiers in Immunology·Giovanni StalloneGiuseppe Grandaliano

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