PMID: 6160322Nov 1, 1980Paper

Plasma concentrations and beta-blocking effects in normal volunteers after intravenous doses of metoprolol and propranolol

Journal of Cardiovascular Pharmacology
C G RegårdhO Rönn

Abstract

The pharmacokinetics of metoprolol and propranolol in 6 healthy volunteers were compared after an intravenous dose of 10 mg of each drug. The mean t1/2, beta was 3.6 hr for both drugs, but due to a larger volume of distribution, the total body clearance was significantly higher for metoprolol (1.20 liters/min) than for propranolol (0.81 liters/min). The individual pharmacokinetic data were used to calculate the doses required to increase the amount of each drug in the body to 10 and 20 mg at 90 and 180 min respectively after an initial intravenous dose of 5.0 mg. The effect on exercise heart rate was determined 30 min after each dose. After identical doses, the two drugs had similar beta-blocking effects in terms of reducing exercise-induced tachycardia. These effects increased with the dose administered. The plasma levels of propranolol were twice as high as those of metoprolol for identical degrees of beta-blockade. The slope of the regression line for the relationship between the beta-blocking effect and log plasma concentrations was the same for the two drugs.

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·C G RegårdhP O Lagerström
Jan 1, 1987·European Journal of Clinical Pharmacology·L J SchaafD G Perrier
Jan 1, 1986·European Journal of Clinical Pharmacology·P H Held, C G Regårdh
Apr 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·J RichardJ Godbillon
Jul 6, 2014·Expert Opinion on Drug Metabolism & Toxicology·Slobodan M Jankovic
Jun 1, 1984·Acta Neurologica Scandinavica·O LidegaardT Korsgaard Larsen
Nov 10, 2018·Clinical Pharmacology and Therapeutics·Kasper Meidahl PetersenMikkel Bring Christensen
May 16, 2019·Journal of Clinical Pharmacology·Sarah KimStephan Schmidt
Aug 5, 1998·The American Journal of Physiology·M V HøjgaardJ K Kanters
Apr 15, 2020·Current Drug Metabolism·Muhammad Nasir KalamNaveed Ahmed
Jun 12, 2021·Critical Care : the Official Journal of the Critical Care Forum·Josée BouchardUNKNOWN EXTRIP workgroup

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