Plasma concentrations and coronary vasodilation after sublingual and intracoronary administration of isosorbide dinitrate

Clinical Cardiology
A HoshioH Mashiba

Abstract

To investigate the relationship between plasma levels and coronary vasodilation after administration of isosorbide dinitrate (ISDN), the plasma concentration and diameters of six segments of the left coronary artery were measured before and after sublingual (SL) ISDN (5 mg) and left intracoronary (IC) administration of ISDN (3 mg) in 12 patients. After SL-ISDN, the systolic aortic pressure decreased with no significant concomitant changes in heart rate or diastolic aortic pressure. After IC-ISDN, all hemodynamic parameters showed significant changes, and these were greater after IC-ISDN than those after SL-ISDN. The individual mean vasodilation of six segments induced by SL- and IC-ISDN, were 23 +/- 9 and 35 +/- 11% (p < 0.01), respectively. Before SL-ISDN, ISDN was not detected in plasma. After SL- and IC-ISDN, however, the plasma values of the ISDN were 36.1 +/- 53.3 and 101.5 +/- 90.0 ng/ml (p < 0.01), respectively. Thus, both coronary vasodilative responses and plasma ISDN levels after IC-ISDN were significantly greater than those after SL-ISDN. However, neither the individual mean coronary vasodilation nor the hemodynamic changes correlated significantly with plasma ISDN levels. Consequently, with administration of the sam...Continue Reading

References

Apr 4, 1975·European Journal of Clinical Pharmacology·L F ChasseaudR K Grundy
Jan 1, 1988·European Heart Journal·M G Bogaert
Dec 1, 1986·Journal of the American College of Cardiology·I SimonettiA L'Abbate
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·M G Bogaert, M T Rosseel
Oct 1, 1970·European Journal of Pharmacology·M G BogaertA F De Schaepdryver
Oct 1, 1970·European Journal of Pharmacology·M G BogaertA F De Schaepdryver
Jun 1, 1983·Clinical Pharmacology and Therapeutics·R A MorrisonH L Fung

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