PMID: 3768488Jul 1, 1986Paper

Plasma concentrations and relative bioavailability of naftidrofuryl from different salt forms

Biopharmaceutics & Drug Disposition
L M WalmsleyJ O Hunter

Abstract

The relative bioavailability of the vasodilator naftidrofuryl from formulations containing its oxalate or citrate salt has been estimated using a specific HPLC assay, and a less specific fluorimetric assay, to measure plasma drug concentrations. The conclusions of the study were the same irrespective of the assay employed. The relative rate, but not the extent, of bioavailability of naftidrofuryl from the citrate salt (peak 1096 ng ml-1 at 0.76 h) was marginally greater (p = 0.003) than that from the oxalate salt (peak 922 ng ml-1 at 0.94 h). The degree of intersubject variability was similar after administration of either salt form. The mean half-life of naftidrofuryl was 1.8 h and its mean residence time was 2.5 h.

References

May 1, 1984·Journal of Pharmaceutical Sciences·E R Garrett
May 1, 1980·The British Journal of Surgery·C A ClyneC W Jamieson
Apr 1, 1981·The British Journal of Surgery·R M Greenhalgh
Oct 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·S Riegelman, P Collier

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Citations

Apr 18, 2000·International Journal of Pharmaceutics·G L EngelL L Winneroski
Nov 4, 2004·Drug Development and Industrial Pharmacy·Beom Soo ShinSun Dong Yoo
May 28, 2005·Journal of Pharmaceutical Sciences·Shoufeng LiAbu T M Serajuddin
Jan 18, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·R K VerbeeckR B Walker

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