Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms

Clinical Biochemistry
Josefin AhnströmB Dahlbäck

Abstract

Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. AAA patients had lower apolipoprotein levels, as compared to healthy individuals: apoA-I, 1.62 vs. 2.08 g/L; apoB, 0.91 vs. 1.04 g/L; apoM, 0.72 vs. 0.91 mumol/L (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively. ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA.

References

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Citations

Aug 31, 2011·Lipids in Health and Disease·Jin-Gang GuXin Zhou
Sep 18, 2010·Lipids in Health and Disease·Guanghua LuoNing Xu
Apr 23, 2015·Molecular Medicine Reports·Li-Zhu HuangYao Zhang
Jan 19, 2010·Clinical Biochemistry·Josefin AhnströmBjörn Dahlbäck
Mar 20, 2015·Thrombosis and Haemostasis·Elena BurilloJose Luis Martin-Ventura
Aug 19, 2014·The British Journal of Surgery·P W StatherM J Bown
Feb 14, 2015·Journal of the American College of Cardiology·Tomoyuki HonjoPrediman K Shah
Dec 24, 2013·Thrombosis Research·Ashfaque A MemonKristina Sundquist
Dec 7, 2017·Medicine and Science in Sports and Exercise·Mark Thomas WindsorChristopher David Askew
Sep 16, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Abrar AhmadAshfaque A Memon
Jun 6, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Jing LiuAlan Daugherty
Aug 2, 2011·Molecular BioSystems·Tania GamberiPietro Amedeo Modesti

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