Plasma concentrations of BDNF and IGF-1 in abstinent cocaine users with high prevalence of substance use disorders: relationship to psychiatric comorbidity

PloS One
María PedrazFrancisco Javier Pavón

Abstract

Recent studies have identified biomarkers related to the severity and pathogenesis of cocaine addiction and common comorbid psychiatric disorders. Monitoring these plasma mediators may improve the stratification of cocaine users seeking treatment. Because the neurotrophic factors are involved in neural plasticity, neurogenesis and neuronal survival, we have determined plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1) and IGF-1 binding protein 3 (IGFBP-3) in a cross-sectional study with abstinent cocaine users who sought outpatient treatment for cocaine (n = 100) and age/body mass matched controls (n = 85). Participants were assessed with the diagnostic interview 'Psychiatric Research Interview for Substance and Mental Disorders'. Plasma concentrations of these peptides were not different in cocaine users and controls. They were not associated with length of abstinence, duration of cocaine use or cocaine symptom severity. The pathological use of cocaine did not influence the association of IGF-1 with age observed in healthy subjects, but the correlation between IGF-1 and IGFBP-3 was not significantly detected. Correlation analyses were performed between these peptides and oth...Continue Reading

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Citations

Jul 20, 2016·BioMed Research International·Peiqing ChenMing Yin
Nov 7, 2017·PloS One·Nuria García-MarchenaFrancisco Javier Pavón
Apr 24, 2019·Journal of Psychopharmacology·Susana Barbosa Méndez, Alberto Salazar-Juárez
Mar 18, 2017·Reviews in the Neurosciences·Raul Felipe Palma-ÁlvarezCarlos Roncero
May 4, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rebeca VidalFrancisco Javier Pavón

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