Plasma concentrations of endothelin-like immunoreactivity in healthy horses and horses with naturally acquired gastrointestinal tract disorders

American Journal of Veterinary Research
Chidambaram M RamaswamyRustin M Moore

Abstract

To compare plasma endothelin (ET)- like immunoreactivity between healthy horses and those with naturally acquired gastrointestinal tract disorders. 29 healthy horses and 142 horses with gastrointestinal tract disorders. Blood samples were collected from healthy horses and from horses with gastrointestinal tract disorders prior to treatment. Magnitude and duration of abnormal clinical signs were recorded, and clinical variables were assessed via thorough physical examinations. Plasma concentrations of ET-like immunoreactivity were measured by use of a radioimmunoassay for human endothelin-1, and CBC and plasma biochemical analyses were performed. Plasma ET-like immunoreactivity concentration was significantly increased in horses with gastrointestinal tract disorders, compared with healthy horses. Median plasma concentration of ET-like immunoreactivity was 1.80 pg/ml (range, 1.09 to 3.2 pg/ml) in healthy horses. Plasma ET-like immunoreactivity was greatest in horses with strangulating large-intestinal obstruction (median, 10.02 pg/ml; range, 3.8 to 22.62 pg/ml), peritonitis (9.19 pg/ml; 789 to 25.83 pg/ml), and enterocolitis (8.89 pg/mI; 6.30 to 18.36 pg/ml). Concentration of ET-like immunoreactivity was significantly associated ...Continue Reading

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Citations

Sep 19, 2009·Journal of Veterinary Internal Medicine·L R R CostaR M Moore
Dec 21, 2002·American Journal of Veterinary Research·Jorge de la CalleRustin M Moore
Nov 19, 2003·American Journal of Veterinary Research·Lisa M KatzJonathan Elliott
Aug 23, 2005·American Journal of Veterinary Research·Ramaswamy M ChidambaramChangaram S Venugopal
May 20, 2005·American Journal of Veterinary Research·Nicola J Menzies-GowCelia M Marr
Mar 4, 2008·American Journal of Veterinary Research·Nicola J Menzies-GowJonathan Elliott
May 27, 2015·Theriogenology·A GiordanoM C Veronesi
Nov 5, 2005·Journal of Applied Physiology·John F PeroniTom P Robertson

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