Plasma concentrations of orexins in children

Annals of Nutrition & Metabolism
Przemyslaw J TomasikKrystyna Sztefko

Abstract

According to experiments done on animals and adult humans, orexins are involved in homeostasis of energy balance, feeding and arousal. The purpose of this study was to evaluate plasma orexins concentrations in children in relation to body mass index (BMI), energy demand and duration of sleep. Studied children were grouped as follows: newborns (n = 7), infants (n = 15), prepubertal children (2-9 years, n = 12), pubertal children (10-15 years, n = 8) and postpubertal adolescents (16-18 years, n = 8). Plasma orexins concentrations were determined by EIA after extraction of samples on Sep-Pak columns. The plasma concentration of orexin A was higher than the concentration of orexin B in all children studied. The concentrations of these two peptides were correlated (r = 0.45, p < 0.03). The highest mean plasma levels of orexin A and B were found in neonates and in children during puberty (orexin A: 1.02 +/- 0.17 ng/ml and 1.01 +/- 0.12 ng/ml, orexin B: 0.67 +/- 0.18 and 0.65 +/- 0.09 ng/ml, respectively) while in other groups the results were significantly lower. A significant negative correlation was found between BMI and the concentrations of orexin A (r = -0.51, p < 0.01) and orexin B (r = -0.45, p < 0.03). A positive correlation ...Continue Reading

References

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Citations

Dec 17, 2009·BMC Gastroenterology·Przemyslaw J Tomasik, Krystyna Sztefko
Aug 9, 2011·The International Journal of Eating Disorders·Jiri BronskyRichard Prusa
Aug 15, 2012·The Journal of Obstetrics and Gynaecology Research·Ercan YilmazSuleyman Aydin
Sep 13, 2014·Neurobiology of Aging·Nicholas J HuntRita Machaalani
Jun 1, 2018·The Journal of Endocrinology·M SkrzypskiM Z Strowski
Feb 26, 2008·Acta Physiologica·M V HeinonenK H Herzig
May 4, 2013·Journal of Applied Physiology·Michael H Chase
Jan 31, 2020·Biology Open·Jacqueline WeidnerChristian Jørgensen
Oct 28, 2016·European Eating Disorders Review : the Journal of the Eating Disorders Association·Sarah SauchelliFernando Fernández-Aranda
Aug 16, 2016·American Journal of Medical Genetics. Part a·Ann M ManzardoMerlin G Butler
Dec 21, 2018·Frontiers in Endocrinology·Kari A MäkeläKarl-Heinz Herzig
May 24, 2016·American Journal of Medical Genetics. Part a·Ann M ManzardoMerlin G Butler
May 13, 2021·Brain Communications·Helene M ÆgidiusBirgitte R Kornum

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