PMID: 702253Oct 1, 1978Paper

Plasma concentrations of phenobarbital in mother and child after combined prenatal and postnatal administration for prophylaxis of hyperbilirubinemia

The Journal of Pediatrics
L O BoréusA Wallin

Abstract

Phenobarbital is known to reduce serum bilirubin concentration in the newborn infant, but optimal dosage is unknown. Ten pregnant women and their infants were given a standard regimen including prenatal maternal administration and postnatal administration to the infant during the first week of life. The plasma levels of phenobarbital in the infants were found to increase during the period of administration, and to remain high for many days beyond the period of hyperbilirubinemia. Optimal dose schedules for phenobarbital should be based both upon pharmacologic effects (including those other than bilirubin disposition) and upon the pharmacokinetic profile of the drug in the newborn infant.

References

Jan 1, 1976·Acta Obstetricia Et Gynecologica Scandinavica·D Trolle
Dec 1, 1973·European Journal of Clinical Pharmacology·B JallingS Agurell
Aug 1, 1972·Archives of Disease in Childhood·F CarswellI R Dunsmore
Jul 1, 1970·The Journal of Pediatrics·L M DubowitzC Goldberg

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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·A Wallin, L Herngren
Jul 1, 1980·European Journal of Clinical Pharmacology·O Pelkonen
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·J M Reinisch, S A Sanders
Jan 1, 1982·Pharmacology & Therapeutics·B M Assael
Dec 1, 1988·Brain Research. Developmental Brain Research·C D JacobsonE Uemura
Apr 5, 2008·Seminars in Fetal & Neonatal Medicine·V E H J Smits-WintjensE Lopriore
Apr 1, 1988·Drug Intelligence & Clinical Pharmacy·P Gal

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