Plasma concentrations of plbatelet-specific proteins in coronary artery disease

Cardiology
I MühlhauserF Kaindl

Abstract

The plasma concentrations of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) were measured in 100 patients with documented coronary artery disease (CAD) and in 40 controls. 18 patients had had coronary artery bypass surgery (CABS), 25 patients were on therapy with beta-blocking agents and 19 were treated with oral anticoagulants. 38 patients with CAD received neither CABS nor beta-blocking or anticoagulating drugs. The highest plasma concentrations of beta-TG and PF4 were found in the patient group without medical or surgical treatment (patients versus controls: p less 0.01). Patients with CABS showed beta-TG and PF4 levels within the normal range. Patients with beta-blocking agents also had lower beta-TG and PF4 values than the patient group without therapy (p less than 0.05). By contrast, patients on oral anticoagulation therapy presented with similar plasma concentrations of beta-TG and PF4 as untreated patients. Our data indicate that surgical or medical treatment with beta-blocking agents, but not with oral anticoagulants, may have some influence on platelet function in patients with CAD. beta-TG and PF4 radioimmunoassay may be a simple method to study platelet involvement in various diseases and to evaluate pos...Continue Reading

Citations

Jul 25, 2003·Journal of Molecular and Cellular Cardiology·Jun Ma, Choong-Chin Liew
Apr 1, 1985·American Heart Journal·M UgarteV Martín-Júdez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.