PMID: 11914190Mar 27, 2002Paper

Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysis

American Journal of Epidemiology
Alain DemersEric Dewailly

Abstract

Some reports indicate that exposure to specific polychlorinated biphenyl (PCB) congeners is related to breast cancer risk. The authors recruited participants in a case-control study from October 1994 to March 1997 to assess the relation between breast cancer risk and concentrations of 14 PCB congeners measured in plasma lipids by high-resolution gas chromatography. Participants were incident cases of breast cancer (n = 314) and controls (n = 523) from the Quebec City region (Canada). Compared with controls, cases had significantly higher concentrations of PCB 99 (p = 0.02), PCB 118 (p = 0.03), and PCB 156 (p = 0.006). Associations were found between breast cancer risk and either PCB 118 (odds ratio (OR) = 1.60, 95% confidence interval (CI): 1.01, 2.53; fourth vs. first quartile) or PCB 156 (OR = 1.80, 95% CI: 1.11, 2.94; fourth vs. first quartile) concentration. Breast cancer risk was also associated with a total concentration of the three mono-ortho-substituted congeners 105, 118, and 156 expressed as 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalents (OR = 2.02, 95% CI: 1.24, 3.28; fourth vs. first quartile). These results suggest that exposure to dioxin-like PCBs increases breast cancer risk. Alternatively, the results ma...Continue Reading

Citations

Dec 9, 2003·Chemosphere·Marian PavukAnton Kocan
Nov 28, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Costabeber, T Emanuelli
Mar 18, 2004·Breast Cancer Research and Treatment·Yvonne Marie Coyle
Jun 11, 2009·Journal of Exposure Science & Environmental Epidemiology·Kristan J AronsonAlvara Morales
Jun 22, 2010·Journal of Toxicology and Environmental Health. Part a·Guillermo Patricio Ortega JacomeSergio Koifman
Sep 3, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yueming ZhuNukhet Aykin-Burns
Oct 8, 2011·Environmental Health : a Global Access Science Source·Eva C Bonefeld-JorgensenEric Dewailly
Oct 25, 2007·Environmental Health : a Global Access Science Source·Manhai LongEva C Bonefeld-Jorgensen
Jun 5, 2008·Environmental Health : a Global Access Science Source·Sam De CosterNik van Larebeke
Nov 9, 2004·Environmental Health Perspectives·Mike HowsamUNKNOWN Bellvitge Colorectal Cancer Group
Oct 6, 2005·Environmental Health Perspectives·Pierre AyotteDaria Pereg
May 17, 2006·Reviews on Environmental Health·David O Carpenter
Jun 11, 2004·Toxicological Reviews·Marcello Lotti
Jun 11, 2004·Toxicological Reviews·Renate D Kimbrough, Constantine A Krouskas
Jan 22, 2013·International Journal of Environmental Research and Public Health·Mayumi TsujiFumio Matsumura
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Fariba SalehiKristan J Aronson
Jan 7, 2016·Environment International·Ling LengNai-Jun Tang
Oct 4, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Tanja KrügerEva C Bonefeld-Jørgensen
Mar 20, 2015·Public Health Nursing·Adelita CantuEster S Carbajal
Aug 4, 2012·Chemosphere·Manhai Long, Eva C Bonefeld-Jørgensen
Nov 29, 2011·International Journal of Hygiene and Environmental Health·Bert MorrensIlse Loots
Jan 2, 2010·Regulatory Toxicology and Pharmacology : RTP·Jian-Ming YangMelanie A Marty
Sep 9, 2009·Environment International·Srivani RavooriRamesh C Gupta
Jan 20, 2016·International Journal of Breast Cancer·Kimberly Mantzke Baker, Angela C Bauer
Jan 5, 2010·Environmental Toxicology and Pharmacology·Joseph E McGraw, Donald P Waller
Aug 12, 2008·Free Radical Biology & Medicine·Venkatasubbaiah A VenkateshaPrabhat C Goswami

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