Plasma concentrations of posaconazole administered via nasogastric tube in patients in a surgical intensive care unit.

Antimicrobial Agents and Chemotherapy
Dominic StörzingerTorsten Hoppe-Tichy

Abstract

Abdominal surgery may affect intestinal absorption and the resulting levels of posaconazole in the blood. We measured plasma posaconazole levels in surgical intensive care unit (SICU) patients and tried to develop a predictive population pharmacokinetics model. A total of 270 samples from 15 patients receiving posaconazole via nasogastric tube were measured by high-performance liquid chromatography (HPLC). SICU patients showed lower plasma drug concentrations, a higher apparent clearance, and a higher volume of distribution than those in hematology patients, possibly due to poor absorption.

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Citations

Sep 24, 2013·Expert Review of Anti-infective Therapy·Seyedmojtaba SeyedmousaviRoger J M Brüggemann
Mar 28, 2018·Antimicrobial Agents and Chemotherapy·Fekade B SimeJason A Roberts
Sep 10, 2014·Antimicrobial Agents and Chemotherapy·Michael J DoltonAndrew J McLachlan
Apr 24, 2020·Drugs·Lu ChenRoger J M Brüggemann
Oct 5, 2018·European Journal of Drug Metabolism and Pharmacokinetics·Zorica JovićMarina Kostić
Dec 30, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Joseph I Boullata
Jun 25, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Simon KalleeUwe Liebchen
Oct 22, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kaitlin L MusickBrian P McKinzie

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