Plasma concentrations of progesterone are higher in the uterine artery than in the radial artery after vaginal administration of micronized progesterone in an oil-based solution to postmenopausal women

Fertility and Sterility
Ettore CicinelliN Einer-Jensen

Abstract

To verify the occurrence of preferential distribution of vaginally administered progesterone to the uterus compared with extrapelvic regions in vivo and in humans. Prospective clinical study. University medical school. Twenty postmenopausal women undergoing transabdominal hysterectomy for benign pathologies. Forty-five minutes before surgery, the women received a single vaginal administration of an oil-based micronized progesterone (100 mg) solution currently available on the market for IM use. During the operation, parallel blood samples were drawn from the uterine and radial arteries. Plasma levels of progesterone were measured by RIA. Mean (+/- SD) plasma levels of progesterone were significantly higher in the uterine artery than in the radial artery (9.75 +/- 3.21 vs. 5.12 +/- 2.06 ng/mL, respectively). Vaginal administration allows a preferential distribution of progesterone to the uterus, which confirms the existence of the so-called "first uterine pass effect."

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Citations

Dec 12, 2012·International Urogynecology Journal·Sushma Srikrishna, Linda Cardozo
Mar 11, 2000·Obstetrics and Gynecology·E CicinelliP Galantino
Dec 8, 2000·Steroids·D de Ziegler, R Fanchin
Oct 26, 2000·Pharmaceutical Science & Technology Today·K Vermani, S Garg
Dec 24, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·N Einer-Jensen, Rhf Hunter
Jun 21, 2013·Drug Development and Industrial Pharmacy·Srinivasan ShanmugamJong Soo Woo
Feb 9, 2016·Reproductive Toxicology·Anthony R ScialliKary E Thompson
Jun 26, 2010·Climacteric : the Journal of the International Menopause Society·C Di CarloC Nappi
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Nov 8, 2015·Reproductive Toxicology·Anthony R ScialliKary E Thompson
May 9, 2003·Reproductive Biomedicine Online·Alan S Penzias, Michael M Alper
May 12, 2009·Advanced Drug Delivery Reviews·Margit M Janát-AmsburyC Matthew Peterson
Nov 6, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ettore Cicinelli
Sep 9, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Walter Ciampaglia, Graciela E Cognigni
Feb 26, 2005·Annals of the New York Academy of Sciences·Ettore CicinelliRoberto Nicoletti
May 14, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Miha LucovnikRobert E Garfield
Nov 26, 2015·The New England Journal of Medicine·Arri CoomarasamyRajendra Rai
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Aug 24, 2012·Obstetrics and Gynecology·Line RodeAnn Tabor
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