Plasma Concentrations of Protein Z and Protein Z-Dependent Protease Inhibitor in Patients With Essential Thrombocythemia

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Anna SzumowskaJanusz Kloczko

Abstract

The pathological consequences of decreased protein Z (PZ) and/or Z-dependent protease inhibitor (ZPI) levels remain as yet unclear, despite a growing body of evidence which supports their involvement in an increased thrombotic risk. The purpose of the present study was 2-fold: to evaluate plasma concentrations of protein Z and ZPI in patients with essential thrombocythemia (ET) and to determine their significance in thrombotic complications. The median (range) plasma concentrations of PZ in our patients with ET were lower, but not significantly, than in healthy individuals: PZ (1.42 µg/mL, 0.36-3.14 µg/mL vs 1.6 µg/mL, 0.75-2.56 µg/mL, P = .08). On the other hand, the median (range) plasma concentrations of ZPI in the said patients with ET were meaningfully lower than in the reference group: ZPI (3.22 µg/mL, 0.85-6.97 µg/mL vs 4.41 µg/mL, 1.63-7.83 µg/mL, P = .0004). More importantly, the study revealed a statistically significant lower concentration of PZ and ZPI in patients with the presence of the JAK2V617F mutation relative to patients without the mutation, for PZ: 1.38 µg/mL, 0.36-2.6 µg/mL versus 1.63 µg/mL, 0.88-3.14 µg/mL, P = .03, and ZPI 2.89 µg/mL, 0.85-5.91 µg/mL versus 3.61 µg/mL, 1.53-6.97 µg/mL, P = .002. Additio...Continue Reading

References

Sep 14, 1990·Biochemical and Biophysical Research Communications·H SejimaK Suzuki
Dec 1, 1981·The Journal of Clinical Investigation·J M HarlanD G Wright
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·X HanG J Broze
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z F YinG J Broze
Oct 23, 2001·Seminars in Thrombosis and Hemostasis·B Kemkes-Matthes, K J Matthes
Sep 13, 2003·Stroke; a Journal of Cerebral Circulation·Andrew M McQuillanVanessa Cole
Dec 4, 2003·Thrombosis and Haemostasis·Sandra FediGian Franco Gensini
Jan 26, 2005·British Journal of Haematology·M A Elliott, A Tefferi
Mar 1, 2005·Thrombosis and Haemostasis·Ali Al-ShanqeetiGeorge J Broze
Dec 20, 2005·Journal of Thrombosis and Haemostasis : JTH·I MartinelliP M Mannucci
Mar 10, 2006·Thrombosis and Haemostasis·Marc VasseJean-Pierre Vannier
May 19, 2006·Journal of Leukocyte Biology·Stefan Rose-JohnSimon A Jones
Dec 21, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Francesca CesariFrancesco Sofi
Aug 27, 2011·Thrombosis Research·Lukasz BolkunJanusz Kloczko
Feb 3, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Marzenna GalarJanusz Kloczko

❮ Previous
Next ❯

Methods Mentioned

BETA
contraception
bone
biopsy
Enzyme-linked Immunosorbent Assay
ELISA

Software Mentioned

Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Marzenna GalarJanusz Kloczko
British Journal of Haematology
Rocio González-ConejeroJavier Corral
© 2021 Meta ULC. All rights reserved