Plasma Concentrations of Select Inflammatory Cytokines Predicts Pain Intensity 48 Hours Post-Shoulder Muscle Injury.

The Clinical Journal of Pain
William C HeddersonSteven Z George

Abstract

The relationship between elevated inflammatory cytokine levels and peak pain intensity following acute musculoskeletal injury has not been fully elucidated in high risk subgroups. Identifying the role that these cytokines have on pain responses may help with developing tailored therapeutic approaches. Data were collected from 54 participants who were vulnerable to a robust pain response and delayed recovery following musculoskeletal injury. Participants completed baseline active and resting pain measurements and a blood draw before an exercised induced shoulder muscle injury. Participants returned at 24 and 48 hours postinjury for follow-up pain measurements and blood draws. Blood plasma was analyzed for interleukin (IL)-1β, IL-6, IL-8, IL-10, and tumor necrosis factor α. Pearson bivariate correlations were performed between cytokines and pain measurements to identify candidate variables for stepwise multiple linear regression predicting pain intensity reports. Pearson bivariate correlation identified 13/45 correlations between inflammatory cytokines and resting pain intensity and 9/45 between inflammatory cytokines and active pain (P<0.05, r≥0.3 or r≤-0.3). This led to 5 stepwise multiple linear regression models, of which 4 m...Continue Reading

References

Nov 1, 1992·British Journal of Pharmacology·F Q CunhaS H Ferreira
Jun 1, 1995·British Journal of Pharmacology·S PooleS H Ferreira
Jun 20, 1998·The Journal of Physiology·K OstrowskiB K Pedersen
Feb 2, 1999·The Journal of Physiology·K OstrowskiB K Pedersen
Apr 18, 2000·Chest·S M Opal, V A DePalo
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaozhong DingJonathan S Bromberg
Mar 17, 2004·Annals of Internal Medicine·Clifford J WoolfUNKNOWN American Physiological Society
Apr 21, 2004·Annals of Internal Medicine·Dennis J SelkoeUNKNOWN American Physiological Society
May 4, 2004·International Immunopharmacology·Marehalli L NagalakshmiRene de Waal Malefyt
Aug 24, 2004·The Clinical Journal of Pain·San KellerCharles S Cleeland
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·T M CunhaS H Ferreira
May 17, 2005·Journal of the American College of Cardiology·Christos Kasapis, Paul D Thompson
Jul 28, 2006·Manual Therapy·Maureen J Simmonds
Feb 6, 2007·The Clinical Journal of Pain·Steven Z GeorgeRoger B Fillingim
Mar 6, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A KochR Freynhagen
Jun 26, 2007·Pain·Gretchen J SummerJon D Levine
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·C Richard ChapmanChan Woo Song
Jan 18, 2008·The Journal of Investigative Dermatology·William H PeranteauKenneth W Liechty
Feb 19, 2008·Neuroscience·O A DinaJ D Levine
Apr 18, 2008·British Journal of Anaesthesia·R D'Mello, A H Dickenson
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin N CouperEleanor M Riley
Dec 17, 2008·The Journal of Hand Surgery·Eric T RicchettiPedro K Beredjiklian
Aug 12, 2009·European Journal of Applied Physiology·Thomas W BufordDarryn S Willoughby
Mar 17, 2010·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Patrick H FinanHoward Tennen
Oct 28, 2010·Physical Medicine and Rehabilitation Clinics of North America·James E Moore
Nov 30, 2010·Archives of Physical Medicine and Rehabilitation·Raphael Scheuer, Martin Friedrich
Dec 22, 2010·British Journal of Anaesthesia·C Voscopoulos, M Lema
Jul 27, 2011·The American Journal of Medicine·Erdal CavusogluDavid J Pinsky
Aug 9, 2011·Seminars in Immunopathology·Charles T Esmon
Sep 29, 2011·Manual Therapy·Thomas RudolfssonMats Djupsjöbacka
Mar 20, 2012·The Journal of Pain : Official Journal of the American Pain Society·Jeffrey J ParrSteven Z George
Apr 10, 2012·CNS & Neurological Disorders Drug Targets·S K SegallL Diatchenko
Jun 23, 2012·Pharmacogenetics and Genomics·Anne Tammimäki, Pekka T Männistö
May 8, 2013·Journal of Leukocyte Biology·Takayuki KimuraShinichi Sato
Sep 12, 2013·Pain·Luis Garcia-Larrea, Roland Peyron
Dec 18, 2013·Nursing Research·Holli A DeVonDebra A Hoppensteadt
Jan 1, 2014·The Journal of Pain : Official Journal of the American Pain Society·Steven Z GeorgeRoger B Fillingim
Mar 8, 2014·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Joseph V PergolizziRobert Taylor
Apr 23, 2014·Current Opinion in Supportive and Palliative Care·Michael H OssipovFrank Porreca
Feb 7, 2015·Journal of Athletic Training·Kelly A Larkin-KaiserSteven Z George

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
blood draws

Clinical Trials Mentioned

NCT02620579

Software Mentioned

SPSS
PASW Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses
Mari A GriffioenCynthia L Renn
Langenbeck's Archives of Surgery
Hans-Georg Schaible, Frank Richter
The Spine Journal : Official Journal of the North American Spine Society
Mark D BishopSteven Z George
© 2021 Meta ULC. All rights reserved