Plasma copeptin as a predictor of kidney disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Sofia EnhörningOlle Melander

Abstract

Plasma copeptin, a marker of vasopressin, is associated with renal function decline in the general population. Our aim was to study the links between elevated copeptin and future risk of kidney disease. Copeptin was measured in a sample of the Malmö Preventive Project (MPP) Reinvestigation (n = 5158) and in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC) (n = 5162). According to national registers, 89 subjects in MPP and 180 in MDC-CC developed chronic kidney disease (CKD) during follow-up (8.7 and 19.6 years, respectively). After multivariate adjustment (gender, age, body mass index, smoking status, estimated glomerular filtration rate, prevalent diabetes, systolic blood pressure and prevalent antihypertensive treatment), copeptin (beta-coefficient per 1 standard deviation increment of ln copeptin) was independently associated with increased risk of CKD during follow-up in both cohorts (MPP: (HR) 1.46, 95% confidence interval (CI) 1.18-1.80, P < 0.001; MDC-CC: HR 1.25, 95% CI 1.02-1.54, P = 0.03) among subjects free from prevalent kidney disease at baseline. Furthermore, in MPP, elevated copeptin predicted a specified diagnosis of kidney disease other than CKD (HR 1.31, 95% CI 1.08-1.59, P = 0.006) after multivariate ...Continue Reading

References

Nov 15, 1979·Biochimica Et Biophysica Acta·S Keppens, H de Wulf
May 1, 1976·The Journal of Clinical Investigation·G Baumann, J F Dingman
Jan 1, 1987·Thrombosis Research·J Filep, B Rosenkranz
Jan 1, 1981·Annual Review of Physiology·J S Handler, J Orloff
Jan 1, 1994·Annual Review of Physiology·M D Breyer, Y Ando
Jan 1, 1993·Journal of Internal Medicine·G BerglundS A Larsson
Jun 15, 1996·The Journal of Clinical Investigation·B K KishoreM A Knepper
Jun 1, 1996·Kidney International·L BankirD Promeneur
Apr 23, 1997·JAMA : the Journal of the American Medical Association·M J KlagJ Stamler
Jun 30, 1998·Endocrinology·C Rabadan-Diehl, G Aguilera
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·P BardouxL Bankir
Jun 28, 2000·International Journal of Epidemiology·L A Johansson, R Westerling
Aug 30, 2002·Metabolism: Clinical and Experimental·Ehab A Abu-BashaWalter H Hsu
Feb 14, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pascale BardouxLise Bankir
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Melanie K HarounJosef Coresh
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Nov 5, 2005·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
May 16, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Vicente E TorresJared J Grantham
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·Panagiotis AnagnostisDimitri P Mikhailidis
May 5, 2010·Circulation·Sofia EnhörningOlle Melander
Jul 27, 2010·General and Comparative Endocrinology·Pascale SmetsSylvie Daminet
Feb 24, 2011·Nephrology·Giovanni F M StrippoliPaul Mitchell
Apr 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Sofia EnhörningOlle Melander
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Jul 13, 2011·Biochimica Et Biophysica Acta·Jill Norman
Sep 3, 2011·Clinical Journal of the American Society of Nephrology : CJASN·William F ClarkAmit X Garg
May 23, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S EnhörningO Melander
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Jun 4, 2013·Lancet·Vivekanand JhaChih-Wei Yang
Jan 1, 2010·Open Access Journal of Urology·Alvaro C UceroAlberto Ortiz
Mar 31, 2015·American Heart Journal·Sofia EnhörningOlle Melander
Apr 7, 2016·The Journal of Clinical Endocrinology and Metabolism·Ronan RousselGilberto Velho

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Citations

Aug 10, 2019·Nutrients·Colleen X Muñoz, Michael Wininger
Jun 13, 2019·International Urology and Nephrology·Maciej FijałkowskiEdyta Golembiewska
Nov 21, 2019·International Journal of Molecular Sciences·Fernando E García-ArroyoL Gabriela Sánchez-Lozada
Mar 30, 2019·Molecular Neurobiology·Bérenger LargeauStephan Ehrmann

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Methods Mentioned

BETA
sandwich immunoassay

Software Mentioned

Stata
SPSS

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