Plasma copeptin levels and prediction of outcome in heart failure outpatients: relation to hyponatremia and loop diuretic doses

Journal of Cardiac Failure
Louise BallingFinn Gustafsson

Abstract

Copeptin, a stable fragment of the vasopressin prohormone, has been shown to be a significant biomarker for morbidity and mortality in heart failure. The aims of this study were to evaluate the influence of plasma sodium on the prognostic significance of copeptin concentrations in heart failure outpatients and to determine whether increased copeptin concentrations predict future development of hyponatremia. A total of 340 heart failure patients with left ventricular systolic dysfunction were followed for 55 months (median) in a Danish heart failure clinic. A baseline measurement of plasma copeptin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and sodium was performed, and the sodium concentrations were recorded during 3 months after the baseline visit in the heart failure clinic. Patients were divided into 3 groups according to copeptin tertiles. In multivariate Cox proportional hazard models adjusted for confounders, including plasma sodium, loop diuretic dose, and NT-proBNP, copeptin was a significant predictor of hospitalization or death (hazard ratio 1.4, 95% confidence interval 1.1-1.9; P < .019) but did not predict mortality independently from NT-proBNP. Additionally, copeptin concentrations did not predict futu...Continue Reading

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Citations

Jan 31, 2014·Current Heart Failure Reports·Marwan F Jumean, Michael S Kiernan
Jul 6, 2014·Heart Failure Reviews·Mark OremusParminder Raina
Sep 17, 2014·Biomarkers in Medicine·Louise Balling, Finn Gustafsson
Mar 20, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Fabian Sanchis-GomarGiuseppe Lippi
May 12, 2015·Disease Markers·Sebastian Johannes ReinstadlerJohannes Mair
Aug 16, 2016·Heart, Lung & Circulation·Stanislava ZabarovskajaLars H Lund
Mar 1, 2017·Journal of Cellular and Molecular Medicine·Jian-Jun YanYong-Hong Yong
Oct 30, 2016·The Journal of International Medical Research·Shuichi KitadaNobuyuki Ohte
Jul 31, 2018·Biomarkers in Medicine·Louise BallingFinn Gustafsson
Nov 20, 2018·Biomarkers in Medicine·Natasa CvetinovicHans-Dirk Düngen
May 14, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Jonas OdermattPhilipp Schuetz
Jul 29, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Nadia AspromonteMarco Migliardi
Feb 10, 2021·Journal of Cellular Physiology·Moein AlaAhmad Reza Dehpour

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