Plasma corticosterone and immune reactivity in restrained female C3H mice

Stress : the International Journal on the Biology of Stress
K S LiP J Neveu

Abstract

Psychological stressors are known to stimulate the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system resulting in the release of corticosterone and catecholamines respectively. They have also been reported to induce cytokine production. All these molecules affect various immune parameters and can alter overall immune competence of the individual. The purpose of this investigation was to study the regulation of the production of corticosterone during stress and its possible effects on immune reactivity. In a first series of experiments, the possible regulation of corticosterone production by interleukin (IL)-1beta and peripheral catecholamines during restraint was assessed using a pharmacological approach in mice. Plasma IL-1beta concentrations remained at basal after 1-h restraint and the stress-induced increase of plasma corticosterone was not modified by a peripheral injection of an IL-1 receptor antagonist (IL-1ra). By contrast, chemical sympathectomy potentiated the restraint-induced increase in plasma corticosterone concentration, this potentiation being reversed by IL-1ra. In a second series of experiments, the role of corticosterone in stress-immune relationships was studied in adrenalectomized mice ...Continue Reading

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Citations

Nov 11, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Do-Hoon KimDong-Keun Song
Feb 18, 2015·Behavioural Brain Research·Yuki OtaToshio Matsuda
Nov 25, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·M Hata, K Ohtsuka
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinghua WangSabita Roy

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