Plasma corticosterone levels in mouse models of pain

European Journal of Pain : EJP
M BenedettiG Lucas

Abstract

Pain markedly activates the hypothalamic-pituitary-adrenal (HPA) axis and increases plasma corticosterone release interfering significantly with nociceptive behaviour as well as the mechanism of action of analgesic drugs. In the present study, we monitored the time course of circulating corticosterone in two mouse strains (C57Bl/6 and Balb/C) under different pain models. In addition, the stress response was investigated following animal handling, intrathecal (i.t.) manipulation and habituation to environmental conditions commonly used in nociceptive experimental assays. We also examined the influence of within-cage order of testing on plasma corticosterone. Subcutaneous injection of capsaicin precipitated a prompt stress response whereas carrageenan and complete Freund's adjuvant induced an increased corticosterone release around the third hour post-injection. However, carrageenan induced a longer increased corticosterone in C57Bl/6 mice. In partial sciatic nerve ligation, neuropathic pain model corticosterone increased only in the first days whereas mechanical hypersensitivity remained much longer. Animal handling also represents an important stressor whereas the i.t. injection per se does not exacerbate the handling-induced s...Continue Reading

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Citations

Jan 25, 2014·Life Sciences·Marcelo R BergaminiCintia H C Saraceni
Apr 26, 2013·ACS Chemical Neuroscience·Hongyan YangAnne M Andrews
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Feb 3, 2021·Scientific Reports·Huy TranKalpna Gupta

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