Plasma corticotropin-releasing factor in depressed patients before and after the dexamethasone suppression test

Biological Psychiatry
R GalardJ M Gallart

Abstract

Plasma cortisol, beta-endorphin, corticotropin, corticotropin-releasing factor, and salivary cortisol concentrations, resting and after ingestion of 1 mg of dexamethasone, were investigated in depressed patients and controls. Fourteen outpatients from the psychiatric department diagnosed with depressive disorder (ICD-10 Classification) participated in the study. The comparison group consisted of 12 healthy volunteers from the hospital staff. All hormones were measured using direct iodine-125 radioimmunoassay, except corticotropin-releasing factor, which included a sample preextraction and concentration step. The basal plasma cortisol and corticotropin-releasing factor levels in depressive disorder were significantly higher than in the healthy group. After dexamethasone administration, corticotropin-releasing factor plasma values decreased significantly in the depressed group, but showed no significant changes in the controls. In depressive disorder baseline values correlated significantly for salivary cortisol and plasma cortisol, salivary cortisol and plasma corticotropin-releasing factor and plasma corticotropin and beta-endorphin. Similar correlations were found in the healthy subjects, except for salivary cortisol and plasm...Continue Reading

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Citations

Feb 5, 2004·Brain, Behavior, and Immunity·Piotr TrzonkowskiAndrzej Myśliwski
Dec 4, 2003·Journal of Occupational Health·Francesco TomeiEnrico Tomao
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Anand GururajanJohn F Cryan
Aug 4, 2009·Neuropeptides·K M HegadorenN Lacaze-Masmonteil
Aug 15, 2015·Neuroscience and Biobehavioral Reviews·R Parrish WatersCliff H Summers
Jun 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Hiroki NozueKunio Ichikawa
Jul 6, 2005·Ageing Research Reviews·Dick F SwaabPaul J Lucassen
Jun 7, 2011·Psychoneuroendocrinology·Royce J LeeAlan Klock
Sep 15, 2004·European Journal of Pharmacology·Darci M NielsenLisa H Gold
Mar 20, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shang-Feng Gao, Ai-Min Bao
Nov 30, 2018·The International Journal of Neuroscience·Verónica TrujilloMarta Magdalena Suárez
Nov 25, 2004·Endocrine Reviews·Roy G SmithYuxiang Sun
Apr 22, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Andrzej WróbelJarosław Dudka

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