Plasma cortisol is increased during the inhibition of LH secretion by central LHRH in the ewe

Neuroendocrinology
D W PorterA M Naylor

Abstract

The delayed and sustained suppression of LH secretion induced by the administration of LHRH into the third cerebral ventricle of the ovariectomized ewe suggests the activation of a neuroendocrine mechanism involving components separate from the LHRH system. Endogenous opioid peptides are involved in regulating LHRH secretion but our recent work shows they do not mediate this inhibition. There is, however, clear evidence for a role for each of the components of the hypothalamopituitary-adrenal axis in the suppression of LHRH/LH secretion. Thus, the relationship between the central administration of LHRH, changes in plasma cortisol and LH secretion was investigated. Injection of LHRH (21 pmol) into the third cerebral ventricle of ovariectomized ewes caused a significant and rapid rise in plasma cortisol to a maximum of 4-5 times pre-injection values, followed by a delayed but sustained reduction in LH secretion. There was a high correlation (r = -0.902) between the increase in cortisol and the reduction in LH. Both the stimulatory effect of central LHRH on plasma cortisol and the inhibitory effect on plasma LH were blocked by prior central treatment with an LHRH antagonist. Intravenous infusion of cortisol, to reach levels observ...Continue Reading

Citations

Feb 1, 1994·Journal of Affective Disorders·G M GoodwinJ Bancroft
Mar 31, 2007·Reproduction, Fertility, and Development·J Santiago-MorenoA López-Sebastián
Dec 24, 1995·Journal of Affective Disorders·J Bancroft, A Cook
Sep 13, 2014·Developmental Psychobiology·Andrew R DismukesElizabeth A Shirtcliff

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