Plasma creatinine medians from patients partitioned by gender and age used as a tool for assessment of analytical stability at different concentrations.

Clinical Chemistry and Laboratory Medicine : CCLM
Steen Ingemann HansenC G Fraser

Abstract

Background Monthly medians of patient results are useful in assessment of analytical quality in medical laboratories. Separate medians by gender makes it possible to generate two independent estimates of contemporaneous errors. However, for plasma creatinine, reference intervals (RIs) are different by gender and also higher over 70 years of age. Methods Daily, weekly and monthly patient medians were calculated from the raw data of plasma creatinine concentrations for males between 18 and 70 years, males >70 years, females between 18 and 70 years and females >70 years. Results The medians of the four groups were all closely associated, with similar patterns. The mean of percentage bias from each group defined the best estimate of bias. The maximum half-range (%) of the bias evaluations provided an estimate of the uncertainty comparable to the analytical performance specifications: thus, bias estimates could be classified as optimum, desirable or minimum quality. Conclusions Medians by gender and age are useful in assessment of analytical stability for plasma creatinine concentration ranging from 60 to 90 μmol/L. The daily medians are valuable in rapid detection of large systematic errors, the weekly medians in detecting minor sy...Continue Reading

References

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Dec 8, 2005·Clinical Chemistry·Gary L MyersUNKNOWN National Kidney Disease Education Program Laboratory Working Group
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Apr 30, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lars Mønster JørgensenGyörgy Sölétormos
Aug 9, 2016·Annals of Clinical Biochemistry·Nuthar JassamJulian H Barth
Apr 28, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Steen Ingemann HansenGyörgy Sölétormos
Jul 20, 2017·Clinical Chemistry·Anna CarobeneUNKNOWN European Biological Variation Study of the EFLM Working Group on Biological Variation
Dec 19, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Steen Ingemann HansenGyörgy Sölétormos

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Citations

Sep 24, 2020·PloS One·Christoffer NyborgJonny Hisdal
Jun 4, 2020·Critical Reviews in Clinical Laboratory Sciences·Tony BadrickUNKNOWN International Federation of Clinical Chemistry and Laboratory Medicine Committee on Analytical Quality

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