Plasma ctDNA monitoring during epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor treatment in patients with EGFR-mutant non-small cell lung cancer (JP-CLEAR trial)

Japanese Journal of Clinical Oncology
Kazuhiro UsuiHideo Kunitoh

Abstract

Osimertinib, a third generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), is active against EGFR-mutant non-small cell lung cancer (NSCLC) resistant to first-/second-generation EGFR-TKIs with the T790M mutation. T790M monitoring in plasma circulating tumor DNA (ctDNA) in patients receiving EGFR-TKIs is less invasive than re-biopsy and could provide valuable clinical information. Patients with advanced or postoperative recurrent NSCLC with sensitizing EGFR mutations who were planned to receive or were receiving first-/second-generation EGFR-TKI treatment without disease progression were eligible for enrollment. Plasma samples at baseline and every 1-2 months thereafter were analyzed for EGFR mutation status using the cobas®EGFR Mutation Test v2. Between September 2016 and March 2017, 122 patients at 15 Japanese institutions were enrolled. In August 2018, 1291 plasma samples from 121 patients were analyzed for EGFR mutation status. At baseline, a sensitizing EGFR mutation was detected in 29 (23.9%) of 121 patients and T790M mutation was detected in three (2.5%). At follow-up, 66 (54.5%) patients experienced disease progression and 64 (52.9%) discontinued first-line EGFR-TKI treatment. Twenty-two (18...Continue Reading

References

Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Mar 25, 2011·Science Translational Medicine·Lecia V SequistJeffrey A Engelman
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Aug 15, 2014·Targeted Oncology·Cecile BoscDenis Moro-Sibilot
Sep 2, 2014·European Respiratory Review : an Official Journal of the European Respiratory Society·Alexis B Cortot, Pasi A Jänne
Sep 13, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Christos ChouaidAlain Vergnenegre
Oct 24, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kenneth S ThressJ Carl Barrett
Dec 14, 2016·The New England Journal of Medicine·Tony S MokUNKNOWN AURA3 Investigators
Apr 22, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Suzanne JenkinsGlenwood D Goss
Jun 15, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Adrian G SacherGeoffrey R Oxnard
Nov 21, 2017·The New England Journal of Medicine·Jean-Charles SoriaUNKNOWN FLAURA Investigators
Jun 10, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christian RolfoDavid R Gandara

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