PMID: 15374079Sep 18, 2004Paper

Plasma cystatin C determinations in a healthy elderly population

Archives of Gerontology and Geriatrics
H FinneyC P Price

Abstract

Plasma cystatin C measurement has been previously shown to be a better indicator of changes in glomerular filtration rate (GFR) than plasma creatinine. The available literature on reference intervals for cystatin C concentration encompasses only paediatric and adult populations up to 60 years of age, therefore we set out to determine an elderly reference range. Blood was taken from 401 subjects (65-101 years) and cystatin C and creatinine concentrations measured using commercially available methodologies. The availability of height and weight measurements allowed the additional calculation of predicted creatinine clearances using the Cockcroft and Gault formulae. Whilst no notable gender difference in cystatin C values was observed (female, 1.48 mg/l; male, 1.53 mg/l), concentrations rose with increasing age (60-79 years, 1.39 mg/l; >80 years, 1.70 mg/l). Conversely, there was a significant (P<0.0001) gender difference in creatinine values (female, 99 micromol/l; male, 120 micromol/l) but none between age groups (60-79 years, 105 micromol/l; >80 years, 113 micromol/l). Calculated GFR determinations resulted in a predicted creatinine clearance range of 21-81 ml/min per 1.73 m2 (n=361). There was no significant difference between...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Oct 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R D Lindeman
Jun 1, 1990·The Biochemical Journal·M AbrahamsonA Grubb
Nov 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·S E BäckP Nilsson-Ehle
Jan 1, 1986·Annals of Clinical Biochemistry·K Spencer
May 1, 1986·Annals of Clinical Biochemistry·R B Payne
Apr 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·O SimonsenH Thysell
Apr 1, 1985·Journal of the American Geriatrics Society·R D LindemanN W Shock
May 29, 1971·Lancet·K Siersbaek-NielsenM Kristensen
Jun 1, 1973·The Journal of Pathology·M S Dunnill, W Halley
Mar 1, 1974·Circulation Research·N K HollenbergJ P Merrill
Oct 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Larsen
Oct 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·P WildingD Robinson
Mar 1, 1973·The Journal of Pathology·E M DarmadyM A Woodhouse
Jan 1, 1972·Annals of Internal Medicine·S A FriedmanW Sy
Apr 30, 1984·Biochemical and Biophysical Research Communications·A J BarrettA Grubb
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A Grubb, H Löfberg
Nov 1, 1984·The American Journal of Medicine·J P BoschS Glabman
Dec 1, 1983·The American Journal of Medicine·J P BoschS Glabman
Jan 1, 1993·Journal of the American Society of Nephrology : JASN·D FliserE Ritz
Apr 1, 1993·The Journal of Clinical Investigation·P SzulcP D Delmas
Sep 1, 1997·Metabolism: Clinical and Experimental·A GiacomelloC P Quaratino
Jul 3, 1998·Geriatric Nephrology and Urology·R D Lindeman
Aug 26, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·E J ErlandsenJ H Kristensen

❮ Previous
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Citations

Jan 1, 2005·Indian Journal of Clinical Biochemistry : IJCB·Purnima Dey SarkarT M Shivaprakash
Mar 3, 2010·International Journal of Hematology·Hideharu MutoHisashi Sakamaki
Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·C P Price, H Finney
Jun 16, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·H FinneyC P Price
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Edmund J LambMichael P Delaney
Jul 23, 2002·Journal of the American Geriatrics Society·Nele J Van Den NoortgateNorbert H Lameire
Mar 31, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maryam NejatZoltán H Endre
Oct 17, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·M M GalteauG Siest
Nov 1, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Sophie Séronie-VivienUNKNOWN SFBC "Biology of renal function and renal failure" working group
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elise WasénKerttu Irjala
Jun 16, 2012·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Timothy V Nguyen, David S Goldfarb
Jan 20, 2007·Clinical Biochemistry·Stefan Herget-RosenthalWalter Hofmann
Sep 5, 2013·Journal of the American Geriatrics Society·Allyson HartUNKNOWN Osteoporotic Fractures in Men Study Group
Jan 30, 2014·British Journal of Clinical Pharmacology·Peter MartusElke S Schaeffner
Jul 12, 2005·Clinical Biochemistry·Hafize UzunSafiye Kaya
May 13, 2014·Journal of Veterinary Internal Medicine·L GhysS Daminet
Sep 11, 2007·Journal of Pharmacological Sciences·Akihiro TanakaHiroaki Araki
Jul 28, 2016·Zeitschrift für Gerontologie und Geriatrie·F Braun, P T Brinkkötter
Dec 18, 2004·Critical Reviews in Clinical Laboratory Sciences·Michele Mussap, Mario Plebani
Dec 22, 2017·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Rajesh JayaramanR Akila
Feb 4, 2012·The American Journal of Clinical Nutrition·Janet E FlatleyHilary J Powers
Nov 26, 2009·Antimicrobial Agents and Chemotherapy·Akihiro TanakaHiroaki Araki
Jun 29, 2012·Oncology Letters·Gen OharaNobuyuki Hizawa
Jul 27, 2011·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Ivana Cláudia GabrielGianna Mastroianni Kirsztajn
May 7, 2021·Biological & Pharmaceutical Bulletin·Kayoko MatsubaraYasuo Takeda

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