Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity

doi:10.1038/ajg.2010.159

PMID: 20407431DOI: 10.1038/ajg.2010.159Apr 22, 2010Paper

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity

The American Journal of Gastroenterology

Paul ScullyEamonn M M Quigley

Abstract

Irritable bowel syndrome (IBS) is a functional disorder that is associated with a number of extra-intestinal co-morbidities and a pro-inflammatory profile. This study was designed to examine the cytokine profile among a group of IBS patients with the extra-intestinal co-morbidities fibromyalgia, premenstrual dysmorphic disorder, and chronic fatigue syndrome. In all, 100 female IBS patients with these co-morbidities, 21 IBS subjects without co-morbidity ("pure" IBS; Rome II), and 54 age-matched female controls took part in the study. Blood was drawn for measurement of the plasma cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p70, IL-13, tumor necrosis factor (TNF)α, and interferon γ. The presence of the selected extra-intestinal manifestations was assessed using standard international criteria. Patients with IBS have increased plasma levels of IL-6 and IL-8; those with these extra-intestinal co-morbidities were found to have, in addition, increased levels of IL-1β and TNFα. No associations were evident between cytokine profiles and the nature of the co-morbidity or number of extra-intestinal co-morbidities present. Although IBS is characterized by a pro-inflammatory profile featuring the pro-inflammatory cytokines IL-6 a...Continue Reading

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