Plasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations

Medicine
Phumla Z SinxadiGary Maartens

Abstract

Efavirenz-based antiretroviral therapy (ART) has been associated with dyslipidemia and dysglycemia, risk factors for cardiovascular disease. However, the pathogenesis is not well understood. We characterized relationships between plasma efavirenz concentrations and lipid and glucose concentrations in HIV-infected South Africans.Participants on efavirenz-based ART were enrolled into a cross-sectional study. The oral glucose tolerance test was performed after an overnight fast, and plasma drawn for mid-dosing interval efavirenz, fasting total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and triglycerides concentrations.Among 106 participants (77 women), median age was 38 years, median CD4 + T-cell count was 322 cells/μL, median duration on ART was 18 months, and median (interquartile range) efavirenz concentration was 2.23 (1.66 to 4.10) μg/mL. On multivariable analyses (adjusting for age, sex, body mass index, and ART duration) doubling of efavirenz concentrations resulted in mean changes in mmol/L (95%CI) of: total cholesterol (0.40 [0.22 to 0.59]), LDL cholesterol (0.19 [0.04 to 0.30]), HDL cholesterol (0.14 [0.07 to 0.20]), triglycerides (0.17 [0.03 to 0.33]), fasting glucose (0.1...Continue Reading

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Citations

Jun 29, 2016·Expert Opinion on Drug Safety·Laia UtrilloPere Domingo
Aug 9, 2016·Expert Review of Clinical Pharmacology·Johannes P MoutonGary Maartens
May 22, 2018·PloS One·Alemayehu AmberbirJoep J van Oosterhout
Dec 20, 2017·Open Forum Infectious Diseases·Josh MuhammadEdgar Turner Overton
May 14, 2019·Infectious Diseases·Stefano NicolèSandro Vento
May 2, 2018·Current HIV/AIDS Reports·Evelyn Hsieh, Michael T Yin
Mar 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Massimiliano LanzafameSandro Vento
Oct 21, 2021·Journal of Medical Microbiology·Hongyan WangYongpeng Shang

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