Plasma endothelin-1 levels in patients with angina pectoris and normal coronary angiograms

American Heart Journal
E HoffmannT M Valenti

Abstract

Some patients with typical angina and electrocardiographic evidence of ischemia have normal coronary angiograms. These patients have a reduced coronary flow reserve and abnormal endothelium-dependent vasodilator responses; this syndrome is known as microvascular angina. Among endothelium-derived peptides, endothelin-1 (ET-1) is a potent vasoconstrictor and an important modulator of microvascular function. Plasma ET-1 was measured in 13 patients with typical angina, instrumental evidence of ischemia, and normal arteriograms and in 20 normal control subjects. Mean concentration of ET-1 was 2.89+/-1.24 pmol/L in patients with angina and normal angiograms and 1.99+/-0.81 pmol/L in normal control subjects (p < 0.02). Plasma levels of ET-1 values were significantly higher in patients with angina, positive exercise test results for ischemia, and normal coronary arteriograms compared with the group of patients with no clinical or instrumental evidence of ischemia. This is consistent with the hypothesis that in patients with microvascular angina, an endothelial dysfunction in the coronary vascular area caused by impaired endothelium-derived ET-1 could play an active role in the disease process.

References

Feb 1, 1991·Journal of the American College of Cardiology·A MaseriT Crake
Oct 23, 1986·The New England Journal of Medicine·P L LudmerP Ganz
Jun 15, 1995·The American Journal of Cardiology·H KrumM Packer
Jan 1, 1993·Cardiology·S QiuB C Solymoss
Jan 1, 1962·American Heart Journal·G G ROWEC W CRUMPTON

❮ Previous
Next ❯

Citations

Jul 27, 1999·Japanese Heart Journal·M Mohri, A Takeshita
May 15, 2010·Cellular Signalling·Al-Karim Khimji, Don C Rockey
Dec 25, 2007·Progress in Cardiovascular Diseases·Narbeh MelikianPhilip A MacCarthy
Jun 19, 2007·European Journal of Internal Medicine·Rahman Shah
Jul 28, 2015·Journal of Molecular and Cellular Cardiology·Naris ThengchaisriLih Kuo
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Wei-Fung BiNen-Chung Chang
Aug 24, 2005·International Journal of Clinical Practice·E A Asbury, P Collins
Mar 8, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jian-Jun LiRui-Tai Hui
Mar 25, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideki FujiiYuhei Kawano
Oct 17, 2008·Journal of cardiology·Hiroaki Shimokawa, Satoshi Yasuda
Jun 14, 2016·Future Cardiology·Olivia Y HungHabib Samady
Oct 21, 2016·Clinical and Experimental Pharmacology & Physiology·Mohamed F Abdel RahmanMohamed Z Gad
Nov 9, 2000·Circulation·G DesideriC Ferri
Nov 19, 2003·Hypertension·Ju-Chi LiuTzu-Hurng Cheng
Feb 1, 2000·The Physician and Sportsmedicine·J D Cantwell, C W Wickliffe
Jul 9, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Michael A ThomasKim-Lien Nguyen
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Catalin LoghinK Lance Gould
Oct 23, 2019·BioMed Research International·Liang LiChao Feng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.