Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease

The Journal of Infectious Diseases
P BrandtzaegE Sørensen

Abstract

We studied prospectively the quantitative relation of circulating endotoxin (lipooligosaccharides [LOSs]) and the development of multiple organ failure and death in 45 consecutively admitted patients with bacteriologically verified systemic meningococcal disease (SMD). A plasma LOS level of greater than 700 ng/L correlated with development of severe septic shock (P less than .0001), adult respiratory distress syndrome (P = .0035), a pathologically elevated serum creatinine level (P less than .0001), or death as a consequence of multiple organ failure (P = .0002). Initial plasma LOS levels of less than 25, 25-700, 700-10,000, and greater than 10,000 ng/L were associated with 0%, 14%, 27%, and 86% fatality, respectively. The LOS half-life after initiation of antibiotic therapy was 1-3 h. Increasing plasma LOS levels were never seen. These observations suggest that LOS quantitation using the limulus amebocyte lysate assay with a chromogenic substrate gives important progsnotic information and may provide new insight concerning pathophysiological aspects of SMD.

Citations

Dec 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M HynninenO Takkunen
Nov 1, 1990·Agents and Actions·D J BrackettM F Wilson
Jan 1, 1993·Immunologic Research·J FigueroaP Densen
May 22, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S C de GreeffM van Deuren
Apr 2, 2005·Antonie van Leeuwenhoek·Liuh Ling GohTiow Suan Sim
Nov 9, 2011·Irish Journal of Medical Science·T C HallA R Dennison
Sep 19, 2003·Current Infectious Disease Reports·Peter Linden
Jul 9, 1991·European Journal of Pharmacology·L Noronha-BlobR M Burch
Apr 18, 1992·Journal of Immunological Methods·R S MunfordP D Rick
Sep 21, 1991·Lancet·M P GlauserJ Cohen
Mar 14, 1992·Lancet·S NadelM Levin
Oct 16, 1993·Lancet·K CartwrightC Constantine
Jan 1, 1989·Regulatory Peptides·P BrandtzaegP K Opstad
Jun 1, 1995·Burns : Journal of the International Society for Burn Injuries·Y M YaoW Y Gao
Jun 27, 2002·Biochemical and Biophysical Research Communications·Douglas D BannermanJohn M Harlan
May 4, 2001·Journal of Immunological Methods·P K LundP Kierulf
Apr 5, 2003·Thrombosis Research·Nina IversenUlrich Abildgaard
Jul 1, 1997·Critical Care Clinics·J A Carcillo, R E Cunnion
Sep 2, 1999·Infectious Disease Clinics of North America·K A Cartwright
Sep 10, 1998·Journal of Clinical Epidemiology·H T SørensenJ Olsen
Feb 1, 2002·FEMS Immunology and Medical Microbiology·Oliver NolteHans Günter Sonntag
Nov 20, 1998·Clinical and Experimental Immunology·J M PrinsS J van Deventer
Jul 12, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Hiromichi SuzukiKenshi Moriwaki
Aug 8, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Kazuyoshi Hanasawa
Sep 5, 2001·The Journal of Infection·R A Wall

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