Plasma enterolignan concentrations and colorectal cancer risk in a nested case-control study

American Journal of Epidemiology
Anneleen KuijstenH Bas Bueno-de-Mesquita

Abstract

Enterolignans are biphenolic compounds that possess several biologic activities whereby they may influence carcinogenesis. The authors investigated the association between plasma enterolactone and enterodiol and colorectal cancer risk in a Dutch prospective study. Among more than 35,000 participants aged 20-59 years, 160 colorectal cancer cases were diagnosed after 7.5 years of follow-up (1987-2003). Cohort members who were frequency-matched to the cases on age, sex, and study center were selected as controls (n = 387). Plasma enterodiol and enterolactone were not associated with risk of colorectal cancer after adjustment for known colorectal cancer risk factors (highest quartile vs. lowest: for enterodiol, odds ratio = 1.11, 95% confidence interval: 0.56, 2.20 (p-trend = 0.75); for enterolactone, odds ratio = 1.70, 95% confidence interval: 0.88, 3.27 (p-trend = 0.15)). However, sex (p-interaction = 0.06) and body mass index (p-interaction < 0.01) modified the relation between plasma enterolactone and colorectal cancer risk; increased risks were observed among women and subjects with a high body mass index. The association between plasma enterodiol and colorectal cancer risk was modified by smoking status; risk was increased am...Continue Reading

Citations

Jul 26, 2013·World Journal of Gastroenterology : WJG·Mariabeatrice PrincipiMichele Barone
Mar 25, 2016·Nutrition and Cancer·Maria HedelinElisabete Weiderpass
Aug 11, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Paige E Miller, Denise C Snyder
Oct 22, 2009·Cancer Causes & Control : CCC·Nina Føns JohnsenAnne Tjønneland
Oct 7, 2010·Cancer Causes & Control : CCC·Maria D JacksonSusan P Walker
Jan 17, 2017·The British Journal of Nutrition·Ruijingfang JiangJenny Chang-Claude
Jun 5, 2019·Critical Reviews in Food Science and Nutrition·Ángela PeiroténJosé M Landete
Sep 11, 2014·World Journal of Gastroenterology : WJG·Mariabeatrice PrincipiAlfredo Di Leo
May 28, 2011·International Journal of Cancer. Journal International Du Cancer·Gerd BobeAmanda J Cross

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